Patient-specific bicuspid valve dynamics: overview of methods and challenges

Krishnan B Chandran; Sarah C Vigmostad

doi:10.1016/j.jbiomech.2012.10.038

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Patient-specific bicuspid valve dynamics: overview of methods and challenges

Journal article

Peer reviewed

Patient-specific bicuspid valve dynamics: overview of methods and challenges

Krishnan B Chandran and Sarah C Vigmostad

Journal of biomechanics, Vol.46(2), pp.208-216

01/18/2013

DOI: 10.1016/j.jbiomech.2012.10.038

PMCID: PMC3552011

PMID: 23182904

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Abstract

About 1-2 % of the babies are born with bicuspid aortic valves instead of the normal aortic valve with three leaflets. A significant portion of the patients with the congenital bicuspid valve morphology suffer from aortic valve stenosis and/or ascending aortic dilatation and dissection thus requiring surgical intervention when they are young adults. Patients with bicuspid aortic valves (BAVs) have also been found to develop valvular stenosis earlier than those with the normal aortic valve. This paper overviews current knowledge of BAVs, where several studies have suggested that the mechanical stresses induced on the valve leaflets and the abnormal flow development in the ascending aorta may be an important factor in the diseases of the valve and the aortic root. The long-term goals of the studies being performed in our laboratory are aimed towards potential stratification of bicuspid valve patients who may be at risk for developing these pathologies based on analyzing the hemodynamic environment of these valves using fluid-structure interaction (FSI) modeling. Patient-specific geometry of the normal tri-cuspid and bicuspid valves are reconstructed from real-time 3D ultrasound images and the dynamic analyses performed in order to determine the potential effects of mechanical stresses on the valve leaflet and aortic root pathology. This paper describes the details of the computational tools and discusses challenges with patient-specific modeling.

Aorta - pathology

Aorta - physiopathology

Aortic Rupture - etiology

Aortic Rupture - pathology

Aortic Rupture - physiopathology

Aortic Valve - abnormalities

Aortic Valve - pathology

Aortic Valve - physiopathology

Aortic Valve Stenosis - etiology

Aortic Valve Stenosis - pathology

Aortic Valve Stenosis - physiopathology

Bicuspid Aortic Valve Disease

Female

Heart Valve Diseases - complications

Heart Valve Diseases - pathology

Heart Valve Diseases - physiopathology

Humans

Male

Models, Cardiovascular

Stress, Physiological

Details

Title: Subtitle: Patient-specific bicuspid valve dynamics: overview of methods and challenges
Creators: Krishnan B Chandran - University of Iowa
Sarah C Vigmostad - University of Iowa
Resource Type: Journal article
Publication Details: Journal of biomechanics, Vol.46(2), pp.208-216
DOI: 10.1016/j.jbiomech.2012.10.038
PMID: 23182904
PMCID: PMC3552011
NLM abbreviation: J Biomech
ISSN: 0021-9290
eISSN: 1873-2380
Grant note: R01 HL109597 / NHLBI NIH HHS HL109597 / NHLBI NIH HHS R01 HL071814 / NHLBI NIH HHS R56 HL071814 / NHLBI NIH HHS HL 071814 / NHLBI NIH HHS
Language: English
Date published: 01/18/2013
Academic Unit: Roy J. Carver Department of Biomedical Engineering; Surgery; Mechanical Engineering
Record Identifier: 9984196559802771

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