Journal article
Patients with Urinary Urgency Have Central Sensitization Symptoms - a LURN II Phenotyping Study
The Journal of urology, Vol.216(1), pp.55-65
07/2026
DOI: 10.1097/JU.0000000000005014
PMCID: PMC13191570
PMID: 41747105
Abstract
To examine central sensitization in patients with urinary urgency, with or without urgency urinary incontinence.
Adult male and female patients who presented with urinary urgency, with or without urgency incontinence, and seeking treatment for their overactive bladder (OAB) were enrolled in the Symptoms of Lower Urinary Tract Dysfunction Research Network (LURN) II Study. A control group without urgency or incontinence was also enrolled. Symptoms associated with central sensitization were assessed using the validated self-reported questionnaire Central Sensitization Inventory (CSI). CSI≥40 is associated with a higher likelihood of having central sensitization.
617 cases with urinary urgency and 125 controls without urinary symptoms were included. Cases had higher CSI part A scores compared to controls (median 28.0 versus 15.0). The percentage of participants likely to have central sensitization (CSI≥40) was significantly higher in cases versus controls (21% versus 3.2%, p<0.001). About one-fourth of OAB cases had symptoms consistent with central sensitization with CSI≥40. CSI≥40 was associated with roughly nine times the odds of being an urgency case compared to CSI<40 (odds ratio 9.17, p<0.001). Higher central sensitization scores correlated with more severe OAB (OAB-q symptom severity, ρ=0.30, p<0.001), urgency symptoms (LURN SI-29 subscale, ρ=0.25, p<0.001), incontinence symptoms (LURN SI-29 subscale, ρ=0.24, p<0.001), and worse quality of life (OAB-q HRQL, ρ=-0.40, p<0.001).
OAB patients with urinary urgency had more central sensitization symptoms compared to controls. Our data suggested that central sensitization may play a role in at least a subset of patients with urinary urgency, with or without UUI.
Details
- Title: Subtitle
- Patients with Urinary Urgency Have Central Sensitization Symptoms - a LURN II Phenotyping Study
- Creators
- H Henry Lai - University of Iowa, UrologyAlan J Fossa - Arbor Research Collaborative for HealthBrian Bieber - Arbor Research Collaborative for HealthCindy L Amundsen - Institute for Female Pelvic Medicine and Reconstructive SurgeryJ Eric Jelovsek - Institute for Female Pelvic Medicine and Reconstructive SurgeryAnne P Cameron - University of MichiganCatherine S Bradley - University of IowaKarl Kreder - University of IowaClaire C Yang - University of WashingtonAlexander Glaser - University of ChicagoVictor P Andreev - Arbor Research Collaborative for HealthKimberly Kenton - Institute for Female Pelvic Medicine and Reconstructive SurgeryJ Quentin Clemens - University of MichiganZiya Kirkali - National Institutes of HealthSteven E Harte - Pain and Headache Center
- Resource Type
- Journal article
- Publication Details
- The Journal of urology, Vol.216(1), pp.55-65
- DOI
- 10.1097/JU.0000000000005014
- PMID
- 41747105
- PMCID
- PMC13191570
- NLM abbreviation
- J Urol
- ISSN
- 1527-3792
- eISSN
- 1527-3792
- Publisher
- LIPPINCOTT WILLIAMS & WILKINS
- Grant note
- National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK), National Institutes of Health (NIH), Duke University: DK097780 University of Iowa: DK097772 University of Chicago: DK097779 University of Michigan Health System: DK099932 University of Washington: DK100011 Washington University in St Louis: DK100017 Arbor Research Collaborative for Health: DK099879 Northwestern University National Institutes of Health's National Center for Advancing Translational Sciences: UL1TR001422
Funding for LURN was obtained under a cooperative agreement from National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK), National Institutes of Health (NIH; Grants DK097780, Duke University; DK097772, University of Iowa; DK097779, University of Chicago; DK099932, University of Michigan Health System; DK100011, University of Washington; DK100017, Washington University in St Louis; and DK099879, Arbor Research Collaborative for Health). Research reported in this publication was supported at Northwestern University, in part, by the National Institutes of Health's National Center for Advancing Translational Sciences, Grant Number UL1TR001422. The content is solely the responsibility of the authors and does not necessarily represent the official views of the National Institutes of Health.
- Language
- English
- Electronic publication date
- 02/26/2026
- Date published
- 07/2026
- Academic Unit
- Epidemiology; Obstetrics and Gynecology; Urology
- Record Identifier
- 9985139495802771
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