Patients with an acute zonal occult outer retinopathy-like illness rapidly improve with valacyclovir treatment

Vinit B Mahajan; Edwin M Stone

doi:10.1016/j.ajo.2010.05.024

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Patients with an acute zonal occult outer retinopathy-like illness rapidly improve with valacyclovir treatment

Journal article

Open access

Peer reviewed

Patients with an acute zonal occult outer retinopathy-like illness rapidly improve with valacyclovir treatment

Vinit B Mahajan and Edwin M Stone

American journal of ophthalmology, Vol.150(4), pp.511-518

10/2010

DOI: 10.1016/j.ajo.2010.05.024

PMCID: PMC4669885

PMID: 20691421

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Abstract

To describe 3 cases of an acute zonal occult outer retinopathy-like illness responsive to valacyclovir hydrochloride. Retrospective, interventional case series. Three patients were treated with valacyclovir and monitored by clinical examination, Goldmann visual field testing, and electroretinography. Patients with an acute zonal occult outer retinopathy-like illness presented following progressive vision loss. This course was immediately reversed by treatment with oral valacyclovir, and visual acuity and visual field improved significantly at 1 week and 1 month. Patients remained stable without treatment during a follow-up period ranging from 1 to 3 years. Some conditions with features of acute zonal occult outer retinopathy may be attributable to a subacute herpetic viral infection that is responsive to oral antiviral medication.

Scotoma - virology

Acyclovir - therapeutic use

Humans

Eye Infections, Viral - drug therapy

Male

Visual Fields

Adult

Female

Retrospective Studies

Retinal Diseases - virology

Scotoma - drug therapy

Electroretinography

Eye Infections, Viral - diagnosis

Acute Disease

Eye Infections, Viral - virology

Retinal Diseases - diagnosis

Scotoma - diagnosis

Acyclovir - analogs & derivatives

Antiviral Agents - therapeutic use

Tomography, Optical Coherence

Valine - analogs & derivatives

Herpesviridae Infections - diagnosis

Herpesviridae Infections - virology

Herpesviridae Infections - drug therapy

Adolescent

Valine - therapeutic use

Visual Field Tests

Retinal Diseases - drug therapy

Details

Title: Subtitle: Patients with an acute zonal occult outer retinopathy-like illness rapidly improve with valacyclovir treatment
Creators: Vinit B Mahajan - Department of Ophthalmology and Visual Sciences, Carver Family Center for Macular Degeneration, University of Iowa, Carver College of Medicine, Iowa City, IA 52242, USA
Edwin M Stone
Resource Type: Journal article
Publication Details: American journal of ophthalmology, Vol.150(4), pp.511-518
DOI: 10.1016/j.ajo.2010.05.024
PMID: 20691421
PMCID: PMC4669885
NLM abbreviation: Am J Ophthalmol
ISSN: 0002-9394
eISSN: 1879-1891
Publisher: Elsevier BV; United States
Grant note: R01 EY016822 / NEI NIH HHS Howard Hughes Medical Institute
Language: English
Date published: 10/2010
Academic Unit: Stead Family Department of Pediatrics; Iowa Neuroscience Institute; Ophthalmology and Visual Sciences
Record Identifier: 9983979913902771

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