Journal article
Patient‐specific quality assurance of dynamically‐collimated proton therapy treatment plans
Medical physics (Lancaster), Vol.51(9), pp.5901-5910
07/08/2024
DOI: 10.1002/mp.17295
PMCID: PMC11781041
PMID: 38977285
Appears in UI Libraries Support Open Access
Abstract
Background The dynamic collimation system (DCS) provides energy layer‐specific collimation for pencil beam scanning (PBS) proton therapy using two pairs of orthogonal nickel trimmer blades. While excellent measurement‐to‐calculation agreement has been demonstrated for simple cube‐shaped DCS‐trimmed dose distributions, no comparison of measurement and dose calculation has been made for patient‐specific treatment plans. Purpose To validate a patient‐specific quality assurance (PSQA) process for DCS‐trimmed PBS treatment plans and evaluate the agreement between measured and calculated dose distributions. Methods Three intracranial patient cases were considered. Standard uncollimated PBS and DCS‐collimated treatment plans were generated for each patient using the Astroid treatment planning system (TPS). Plans were recalculated in a water phantom and delivered at the Miami Cancer Institute (MCI) using an Ion Beam Applications (IBA) dedicated nozzle system and prototype DCS. Planar dose measurements were acquired at two depths within low‐gradient regions of the target volume using an IBA MatriXX ion chamber array. Results Measured and calculated dose distributions were compared using 2D gamma analysis with 3%/3 mm criteria and low dose threshold of 10% of the maximum dose. Median gamma pass rates across all plans and measurement depths were 99.0% (PBS) and 98.3% (DCS), with a minimum gamma pass rate of 88.5% (PBS) and 91.2% (DCS). Conclusions The PSQA process has been validated and experimentally verified for DCS‐collimated PBS. Dosimetric agreement between the measured and calculated doses was demonstrated to be similar for DCS‐collimated PBS to that achievable with noncollimated PBS.
Details
- Title: Subtitle
- Patient‐specific quality assurance of dynamically‐collimated proton therapy treatment plans
- Creators
- Laura C. Bennett - University of IowaDaniel E. Hyer - University of IowaJustin Vu - University of IowaKaustubh Patwardhan - University of IowaKevin Erhart - .decimal LLC Sanford Florida USAAlonso N. Gutierrez - Baptist Health South FloridaEduardo Pons - Baptist Health South FloridaEric Jensen - Ion Beam ApplicationsManual Ubau - Ion Beam ApplicationsJulio Zapata - Ion Beam Applications S.A., R&D Proton Therapy Louvain‐La‐Neuve BelgiumAndrew Wroe - Baptist Hospital of MiamiKarsten Wake - University of Wisconsin–MadisonNicholas P. Nelson - University of Wisconsin–MadisonWesley S. Culberson - University of Wisconsin–MadisonBlake R. Smith - University of IowaPatrick M. Hill - University of Wisconsin–MadisonRyan T. Flynn - University of Iowa
- Resource Type
- Journal article
- Publication Details
- Medical physics (Lancaster), Vol.51(9), pp.5901-5910
- DOI
- 10.1002/mp.17295
- PMID
- 38977285
- PMCID
- PMC11781041
- NLM abbreviation
- Med Phys
- ISSN
- 0094-2405
- eISSN
- 2473-4209
- Publisher
- Wiley
- Grant note
- National Cancer Institute National Institutes of Health. Grant Number: R37CA226518
- Language
- English
- Electronic publication date
- 07/08/2024
- Academic Unit
- Roy J. Carver Department of Biomedical Engineering; Radiation Oncology
- Record Identifier
- 9984656634302771
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