Journal article
Pattern matching in a model of dendritic spines
Network (Bristol), Vol.9(1), pp.107-121
02/1998
DOI: 10.1088/0954-898X_9_1_006
PMID: 9861981
Abstract
Pattern matching, the ability to recognize and maximally respond to an input pattern that is similar to a previously learned pattern, is an essential step in any learning process. To investigate the properties of pattern matching in biological neurons, and in particular the role of a calcium-dependent potassium conductance, a circuit model of a small area of dendritic membrane with a number of dendritic spines is developed. Circuit model simulations show that dendritic membrane depolarization is greater in response to a previously learned pattern of synaptic inputs than in response to a novel pattern of synaptic inputs. These simulations, in combination with an analysis of the circuit model equations, reveal that when a synaptic input pattern is similar to the learned pattern of synaptic inputs, the total dendritic depolarization is a linear combination of dendritic depolarization contributed by individual spines. When at least one synaptic input differs markedly from the learned value, dendritic depolarization is a nonlinear combination of individual spine depolarizations. These principles of spine interactions are captured in a computationally simple set of 'similarity measure' equations which are shown to reproduce the response surface of the circuit model output. Thus, these similarity measure equations not only describe a biologically plausible model of pattern matching, they also satisfy computational requirements for use in artificial neural networks.
Details
- Title: Subtitle
- Pattern matching in a model of dendritic spines
- Creators
- K T Blackwell - Environmental Research Institute of MichiganT P Vogl - Environmental Research Institute of MichiganD L Alkon - National Institute of Neurological Disorders and Stroke
- Resource Type
- Journal article
- Publication Details
- Network (Bristol), Vol.9(1), pp.107-121
- DOI
- 10.1088/0954-898X_9_1_006
- PMID
- 9861981
- NLM abbreviation
- Network
- ISSN
- 0954-898X
- eISSN
- 1361-6536
- Publisher
- Informa UK Ltd
- Language
- English
- Date published
- 02/1998
- Academic Unit
- Roy J. Carver Department of Biomedical Engineering; Iowa Neuroscience Institute
- Record Identifier
- 9984446548902771
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