Journal article
Pattern of brain morphology in patients with schizophrenia and large cavum septi pellucidi
The journal of neuropsychiatry and clinical neurosciences, Vol.8(2), pp.147-152
1996
DOI: 10.1176/jnp.8.2.147
PMID: 9081549
Abstract
Cavum septi pellucidi (CSP) is a midline developmental anomaly shown to have increased incidence in patients with schizophrenia. The etiology of CSP may involve dysgenesis of the temporal lobes. This study evaluated the pattern of brain changes in three groups: 1) normal control subjects, 2) schizophrenic subjects without large CSP, and 3) schizophrenic subjects with large CSP. Patients without large CSP had decreased total brain, frontal, and temporal lobe volumes; patients with the anomaly had more pronounced right > left asymmetry and volume decrement limited to the left temporal lobe. These findings indicate that patients with schizophrenia and large CSP may show a different pattern of disturbed brain morphology than patients without this abnormality.
Details
- Title: Subtitle
- Pattern of brain morphology in patients with schizophrenia and large cavum septi pellucidi
- Creators
- P Nopoulos - University of Iowa Hospitals and Clinics, Mental Health Clinical Research Center, Iowa City, IA 52242, USAV SwayzeN C Andreasen
- Resource Type
- Journal article
- Publication Details
- The journal of neuropsychiatry and clinical neurosciences, Vol.8(2), pp.147-152
- Publisher
- United States
- DOI
- 10.1176/jnp.8.2.147
- PMID
- 9081549
- ISSN
- 0895-0172
- eISSN
- 1545-7222
- Grant note
- MH 40856 / NIMH NIH HHS MH 31593 / NIMH NIH HHS MHCRC43271 / NIMH NIH HHS
- Language
- English
- Date published
- 1996
- Academic Unit
- Neurology; Psychiatry; Stead Family Department of Pediatrics; Iowa Neuroscience Institute
- Record Identifier
- 9984004078802771
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