Patterns and predictors of fatigue following living donor nephrectomy: Findings from the KDOC Study

James R Rodrigue; Aaron Fleishman; Jesse D Schold; Paul Morrissey; James Whiting; John Vella; Liise K Kayler; Daniel A Katz; Jody Jones; Bruce Kaplan; Martha Pavlakis; Didier A Mandelbrot; KDOC Study Group

doi:10.1111/ajt.15519

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Patterns and predictors of fatigue following living donor nephrectomy: Findings from the KDOC Study

Journal article

Open access

Peer reviewed

Patterns and predictors of fatigue following living donor nephrectomy: Findings from the KDOC Study

James R Rodrigue, Aaron Fleishman, Jesse D Schold, Paul Morrissey, James Whiting, John Vella, Liise K Kayler, Daniel A Katz, Jody Jones, Bruce Kaplan, …

American journal of transplantation, Vol.20(1), pp.181-189

01/2020

DOI: 10.1111/ajt.15519

PMID: 31265199

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Abstract

This study sought to identify the prevalence, pattern, and predictors of clinical fatigue in 193 living kidney donors (LKDs) and 20 healthy controls (HCs) assessed at predonation and 1, 6, 12, and 24 months postdonation. Relative to HCs, LKDs had significantly higher fatigue severity (P = .01), interference (P = .03), frequency (P = .002), and intensity (P = .01), and lower vitality (P < .001), at 1-month postdonation. Using published criteria, significantly more LKDs experienced clinical fatigue at 1 month postdonation, compared to HCs, on both the Fatigue Symptom Inventory (60% vs. 37%, P < .001) and SF-36 Vitality scale (67% vs. 16%, P < .001). No differences in fatigue scores or clinical prevalence were observed at other time points. Nearly half (47%) reported persistent clinical fatigue from 1 to 6 months postdonation. Multivariable analyses demonstrated that LKDs presenting for evaluation with a history of affective disorder and low vitality, those with clinical mood disturbance and anxiety about future kidney failure after donation, and those with less physical activity engagement were at highest risk for persistent clinical fatigue 6 months postdonation. Findings confirm inclusion of fatigue risk in existing OPTN informed consent requirements, have important clinical implications in the care of LKDs, and underscore the need for further scientific examination in this population.

Adult

Fatigue - diagnosis

Fatigue - epidemiology

Fatigue - etiology

Female

Follow-Up Studies

Humans

Kidney Transplantation - methods

Living Donors - supply & distribution

Male

Nephrectomy - adverse effects

Postoperative Complications - diagnosis

Postoperative Complications - epidemiology

Postoperative Complications - etiology

Prognosis

Prospective Studies

Quality of Life

Tissue and Organ Harvesting - adverse effects

United States - epidemiology

Details

Title: Subtitle: Patterns and predictors of fatigue following living donor nephrectomy: Findings from the KDOC Study
Creators: James R Rodrigue - Beth Israel Deaconess Medical Center
Aaron Fleishman - Beth Israel Deaconess Medical Center
Jesse D Schold - Cleveland Clinic
Paul Morrissey - Rhode Island Hospital
James Whiting - Maine Medical Center
John Vella - Maine Medical Center
Liise K Kayler - Erie County Medical Center
Daniel A Katz - University of Iowa
Jody Jones - University of Iowa
Bruce Kaplan - University of Arizona
Martha Pavlakis - Harvard University
Didier A Mandelbrot - University of Wisconsin–Madison
KDOC Study Group
Resource Type: Journal article
Publication Details: American journal of transplantation, Vol.20(1), pp.181-189
DOI: 10.1111/ajt.15519
PMID: 31265199
NLM abbreviation: Am J Transplant
ISSN: 1600-6135
eISSN: 1600-6143
Grant note: R01DK085185 / NIDDK NIH HHS
Language: English
Date published: 01/2020
Academic Unit: Psychological and Brain Sciences; Surgery
Record Identifier: 9984321864602771

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