Journal article
Patterns of Association between Depressive Symptoms and Chronic Medical Morbidities in Older Adults
Journal of the American Geriatrics Society (JAGS), Vol.68(8), pp.1834-1841
08/01/2020
DOI: 10.1111/jgs.16468
PMCID: PMC7879564
PMID: 32402115
Abstract
OBJECTIVES To investigate the association between depressive symptoms and several medical morbidities, and their combination, in a large older population.
DESIGN Cross-sectional study of baseline data from the ASPirin in Reducing Events in the Elderly (ASPREE) trial.
SETTING Multicentric study conducted in Australia and the United States.
PARTICIPANTS A total of 19,110 older adults (mean age = 75 years [standard deviation = +/- 4.5]).
MEASUREMENTS Depressive symptoms were measured using the Center for Epidemiological Studies Depression (CES-D 10) scale. Medical morbidities were defined according to condition-specific methods. Logistic regression was used to calculate odds ratios (ORs) with 95% confidence intervals (CIs) to test associations before and after accounting for possible confounders.
RESULTS Depressive symptoms were significantly associated with obesity (OR = 1.19; 95% CI = 1.07-1.32), diabetes (OR = 1.22; 95% CI = 1.05-1.42), gastroesophageal reflux disease (GERD) (OR = 1.41; 95% CI = 1.28-1.57), metabolic syndrome (OR = 1.16; 95% CI = 1.03-1.29), osteoarthritis (OR = 1.41; 95% CI = 1.27-1.57), respiratory conditions (OR = 1.25; 95% CI = 1.10-1.42), history of cancer (OR = 1.19; 95% CI = 1.05-1.34), Parkinson's disease (OR = 2.56; 95% CI = 1.83-3.56), polypharmacy (OR = 1.60; 95% CI = 1.44-1.79), and multimorbidity (OR = 1.29; 95% CI = 1.12-1.49). No significant association was observed between depressive symptoms and hypertension, chronic kidney disease, dyslipidemia, and gout (P > .05). A significant dose-response relationship was evident between the number of medical comorbidities and the prevalence of depression (OR = 1.18; 95% CI = 1.13-1.22).
CONCLUSION Late-life depressive symptoms are significantly associated with several medical morbidities, and there appears to be a cumulative effect of the number of somatic diseases on the prevalence of depression. These findings augment the evidence for a complex relationship between mental and physical health in an otherwise healthy older population and might guide clinicians toward early recognition of high-risk individuals.
Details
- Title: Subtitle
- Patterns of Association between Depressive Symptoms and Chronic Medical Morbidities in Older Adults
- Creators
- Bruno Agustini - Deakin UniversityMojtaba Lotfaliany - Deakin UniversityRobyn L. Woods - Monash UniversityJohn J. McNeil - Monash UniversityMark R. Nelson - Menzies Research InstituteRaj C. Shah - Rush University Medical CenterAnne M. Murray - Berman Center for Outcomes and Clinical ResearchMichael E. Ernst - Roy J. and Lucille A. Carver College of MedicineChristopher M. Reid - Monash UniversityAndrew Tonkin - Monash UniversityJessica E. Lockery - Monash UniversityLana J. Williams - Deakin UniversityMichael Berk - Florey Institute of Neuroscience and Mental HealthMohammadreza Mohebbi - Deakin UniversityASPREE Investigator Group
- Resource Type
- Journal article
- Publication Details
- Journal of the American Geriatrics Society (JAGS), Vol.68(8), pp.1834-1841
- DOI
- 10.1111/jgs.16468
- PMID
- 32402115
- PMCID
- PMC7879564
- NLM abbreviation
- J Am Geriatr Soc
- ISSN
- 0002-8614
- eISSN
- 1532-5415
- Publisher
- Wiley
- Number of pages
- 8
- Grant note
- 1064272 / National Health and Medical Research Council (NHMRC); National Health and Medical Research Council (NHMRC) of Australia 1174060; 1059660; 1156072; 1045862 / NHMRC; National Health and Medical Research Council (NHMRC) of Australia
- Language
- English
- Date published
- 08/01/2020
- Academic Unit
- Family and Community Medicine; Pharmacy Practice and Science
- Record Identifier
- 9984297344602771
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