Journal article
Patterns of Body Composition Among HIV-Infected, Pregnant Malawians and the Effects of Famine Season
Maternal and child health journal, Vol.17(2), pp.265-273
02/01/2013
DOI: 10.1007/s10995-012-0970-6
PMCID: 3837416
PMID: 22395817
Abstract
We describe change in weight, midupper arm circumference (MUAC), arm muscle area (AMA) and arm fat area (AFA) in 1130 pregnant HIV-infected women with CD4 counts > 200 as part of the BAN Study (http://www.thebanstudy.org), a randomized, controlled clinical trial to evaluate antiretroviral and nutrition interventions to reduce mother-to-child transmission of HIV during breast feeding. In a longitudinal analysis, we found a linear increase in weight with a mean rate of weight gain of 0.27 kgs/week, from baseline (12 to 30 weeks gestation) until the last follow-up visit (32-38 weeks). Analysis of weight gain showed that 17.1% of the intervals between visits resulted in a weight loss. In unadjusted models, MUAC and AMA increased and AFA declined during late pregnancy. Based on multivariable regression analysis, exposure to the famine season resulted in larger losses in AMA [-0.08, 95% CI -0.14, -0.02; p = 0.01] while AFA losses occurred irrespective of season [-0.55, 95%: -0.95, -0.14, p = 0.01]. CD4 was associated with AFA [0.21, 95% CI 0.01, 0.41, p = .04]. Age was positively associated with MUAC and AMA. Wealth was positively associated with MUAC, AFA, and weight. While patterns of anthropometric measures among HIV-infected, pregnant women were found to be similar to those reported for uninfected women in sub-Saharan Africa, effects of the famine season among undernourished, Malawian women are of concern. Strategies to optimize nutrition during pregnancy for these women appear warranted.
Details
- Title: Subtitle
- Patterns of Body Composition Among HIV-Infected, Pregnant Malawians and the Effects of Famine Season
- Creators
- Roshan T. Ramlal - University of North Carolina at Chapel HillMartin Tembo - UNC Project, Lilongwe, MalawiAlice Soko - UNC Project, Lilongwe, MalawiMaggie Chigwenembe - UNC Project, Lilongwe, MalawiBeth C. Tohill - Centers for Disease Control and PreventionDumbani Kayira - UNC Project, Lilongwe, MalawiCaroline C. King - Centers for Disease Control and PreventionCharles Chasela - UNC Project, Lilongwe, MalawiDenise Jamieson - Centers for Disease Control and PreventionCharles van der Horst - University of North Carolina at Chapel HillMargaret E. Bentley - University of North Carolina at Chapel HillLinda S. Adair - University of North Carolina at Chapel HillBreastfeeding, Antiretrovirals and Nutrition (BAN) Study Team
- Resource Type
- Journal article
- Publication Details
- Maternal and child health journal, Vol.17(2), pp.265-273
- Publisher
- Springer Nature
- DOI
- 10.1007/s10995-012-0970-6
- PMID
- 22395817
- PMCID
- 3837416
- ISSN
- 1092-7875
- eISSN
- 1573-6628
- Number of pages
- 9
- Language
- English
- Date published
- 02/01/2013
- Academic Unit
- Obstetrics and Gynecology; VPMA - Administration
- Record Identifier
- 9984446544902771
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