Patterns of compartment involvement in tibiofemoral osteoarthritis in men and women and in whites and African Americans

Barton L Wise; Jingbo Niu; Mei Yang; Nancy E Lane; William Harvey; David T Felson; Jean Hietpas; Michael Nevitt; Leena Sharma; Jim Torner; C E Lewis; Yuqing Zhang; Multicenter Osteoarthritis (MOST) Group

doi:10.1002/acr.21606

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Patterns of compartment involvement in tibiofemoral osteoarthritis in men and women and in whites and African Americans

Journal article

Open access

Peer reviewed

Patterns of compartment involvement in tibiofemoral osteoarthritis in men and women and in whites and African Americans

Barton L Wise, Jingbo Niu, Mei Yang, Nancy E Lane, William Harvey, David T Felson, Jean Hietpas, Michael Nevitt, Leena Sharma, Jim Torner, …

Arthritis care & research (2010), Vol.64(6), pp.847-852

06/2012

DOI: 10.1002/acr.21606

PMCID: PMC3340516

PMID: 22238208

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Abstract

We conducted a cross-sectional study to describe the prevalence of tibiofemoral joint space narrowing (JSN) in medial and lateral compartments and assess whether it differs by sex and ethnic groups, and, if it does, to what extent such a difference is accounted for by knee malalignment. The Multicenter Osteoarthritis Study is an observational study of persons ages 50-79 years with either symptomatic knee osteoarthritis or high risk of disease. Knee radiographs were assessed for JSN in each tibiofemoral compartment. Mechanical axis angle was measured using full-extremity films. We compared the proportion of knees with medial compartment JSN and with lateral JSN between men and women, as well as between whites and African Americans, using a logistic regression model adjusting for covariates (race or sex and body mass index, age, education, and clinic site). We used generalized estimating equations to account for correlation between 2 knees within a person. Of 5,202 knees (2,652 subjects), 1,532 (29.5%) had medial JSN and 427 (8.2%) had lateral JSN. Lateral JSN was more prevalent in the knees of women than in men (odds ratio [OR] 1.9, 95% confidence interval [95% CI] 1.5-2.4) and was also higher in the knees of African Americans than in whites (OR 2.4, 95% CI 1.7-3.3). Further adjustment for malalignment attenuated the OR for sex but not the OR for race. Women and African Americans are more likely to have lateral JSN than men and whites, respectively. Valgus malalignment may contribute to the higher prevalence in women.

Radiography

Bone Malalignment - epidemiology

Prevalence

Cross-Sectional Studies

Humans

Middle Aged

Knee Joint - diagnostic imaging

Tibia - diagnostic imaging

Logistic Models

Male

Femur - diagnostic imaging

Sex Characteristics

European Continental Ancestry Group - ethnology

Osteoarthritis, Knee - diagnostic imaging

Osteoarthritis, Knee - ethnology

Disease Progression

African Americans - ethnology

Bone Malalignment - diagnostic imaging

Female

Aged

Details

Title: Subtitle: Patterns of compartment involvement in tibiofemoral osteoarthritis in men and women and in whites and African Americans
Creators: Barton L Wise - Musculoskeletal and Aging Research Group, University of California-Davis School of Medicine, 4625 2nd Avenue, Sacramento, CA 95817, USA. barton.wise@ucdmc.ucdavis.edu
Jingbo Niu
Mei Yang - Boston University
Nancy E Lane
William Harvey
David T Felson
Jean Hietpas
Michael Nevitt
Leena Sharma
Jim Torner
C E Lewis
Yuqing Zhang
Multicenter Osteoarthritis (MOST) Group
Resource Type: Journal article
Publication Details: Arthritis care & research (2010), Vol.64(6), pp.847-852
DOI: 10.1002/acr.21606
PMID: 22238208
PMCID: PMC3340516
NLM abbreviation: Arthritis Care Res (Hoboken)
ISSN: 2151-464X
eISSN: 2151-4658
Publisher: United States
Grant note: U01 AG018947 / NIA NIH HHS U01 AG018832 / NIA NIH HHS U01 AG018832-05 / NIA NIH HHS U01 AG18832 / NIA NIH HHS U01 AG019069 / NIA NIH HHS K12-HD-051958 / NICHD NIH HHS K12 HD051958 / NICHD NIH HHS R01 AR048748 / NIAMS NIH HHS UO1-AG18947 / NIA NIH HHS P50-AR060752 / NIAMS NIH HHS K12 HD051958-06 / NICHD NIH HHS R01 HD043500 / NICHD NIH HHS R01-HD-43500 / NICHD NIH HHS UO1-AG19069 / NIA NIH HHS U01 AG018947-05 / NIA NIH HHS P50 AR060752 / NIAMS NIH HHS R01 HD043500-03 / NICHD NIH HHS U01 AG019069-09 / NIA NIH HHS U01 AG018820 / NIA NIH HHS UO1-AG18820 / NIA NIH HHS U01 AG018820-08 / NIA NIH HHS
Language: English
Date published: 06/2012
Academic Unit: Epidemiology; Surgery; Injury Prevention Research Center; Neurosurgery
Record Identifier: 9983995043002771

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