Journal article
Pediatric Celiac Disease and Eosinophilic Esophagitis: Outcome of Dietary Therapy
Journal of pediatric gastroenterology and nutrition, Vol.69(2), pp.E43-E48
08/01/2019
DOI: 10.1097/MPG.0000000000002343
PMID: 30921260
Abstract
Objective: The coexistence of celiac disease (CeD) and eosinophilic esophagitis (EoE) in pediatric patients has been increasingly recognized. In the current study, we have aimed to assess the outcomes of therapeutic dietary interventions in a cohort of pediatric patients with CeD and EoE. Methods: Pediatric patient records obtained from the University of Chicago Celiac Center Database from August 2008 to July 2013 were reviewed. Information was collected on patients with concomitant CeD and EoE regarding age, sex, dates of diagnoses, presenting symptoms, length of symptoms before diagnosis, familial and personal atopic history, dietary therapy, and esophageal histologic response to dietary therapy. Results: A total of 350 records of patients with CeD were reviewed. Twenty-two (6.3%) had a confirmed diagnosis of CeD and EoE, 17 had repeat biopsies. Four of 17 (23.5%) had resolution of esophageal eosinophilia on an exclusive gluten-free diet, 10 of 17 (59%) required additional eliminations to show histologic resolution, 1 of 17 (6%) had not reached histological remission, and 2 of 17 (12%) were lost to follow-up. Success rates of single food reintroductions were: soy 5 of 5 (100%), eggs 3 of 5 (60%), dairy 3 of 7 (43%), nuts 2 of 4 (50%), and fish 2 of 4 (50%). Conclusions: To our knowledge, this is the largest pediatric study to assess the histologic outcome of EoE-associated esophageal eosinophilia in response to dietary management of pediatric patients with concomitant CeD and EoE. We demonstrate that soy is well tolerated in this cohort, and suggest that reintroducing this food first, or trialing a soy-inclusive elimination diet is a viable strategy.
Details
- Title: Subtitle
- Pediatric Celiac Disease and Eosinophilic Esophagitis: Outcome of Dietary Therapy
- Creators
- Tiffany Patton - Comer Children's HospitalAnkur Chugh - Medical College of WisconsinLeena Padhye - Rush University Medical CenterCatherine DeGeeter - University of IowaStefano Guandalini - Comer Children's Hospital
- Resource Type
- Journal article
- Publication Details
- Journal of pediatric gastroenterology and nutrition, Vol.69(2), pp.E43-E48
- DOI
- 10.1097/MPG.0000000000002343
- PMID
- 30921260
- NLM abbreviation
- J Pediatr Gastroenterol Nutr
- ISSN
- 0277-2116
- eISSN
- 1536-4801
- Publisher
- Lippincott Williams & Wilkins
- Number of pages
- 6
- Language
- English
- Date published
- 08/01/2019
- Academic Unit
- Stead Family Department of Pediatrics; Gastroenterology, Hepatology, Pancreatology, and Nutrition
- Record Identifier
- 9984353826202771
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