Journal article
Pediatric surgery and the human microbiome
Journal of pediatric surgery, Vol.46(3), pp.577-584
03/2011
DOI: 10.1016/j.jpedsurg.2010.12.018
PMID: 21376215
Abstract
Bold advances in the past decade have made it possible to carefully study the contributions of microbes to normal human development and to disease pathogenesis. The intestinal microbiota has been implicated in adult diseases ranging from obesity to cancer, but there have been relatively few investigations of bacteria in surgical diseases of infancy and childhood. In this review, we discuss how novel culture-independent approaches have been harnessed to profile microbes present within clinical specimens. Unique features of the pediatric microbiota and innovative approaches to manipulate the gut flora are also reviewed. Finally, we detail the contributions of gut microbes to 3 diseases relevant to pediatric surgeons: necrotizing enterocolitis, obesity, and inflammatory bowel disease. Current and future research regarding the pediatric microbiota is likely to translate to improved outcomes for infants and children with surgical diseases.
Details
- Title: Subtitle
- Pediatric surgery and the human microbiome
- Creators
- Erica M Carlisle - Department of Surgery, The University of Chicago Pritzker School of Medicine, Chicago, IL, USAMichael J Morowitz - Department of Surgery, University of Pittsburgh School of Medicine, Pittsburgh, PA 15224, USA
- Resource Type
- Journal article
- Publication Details
- Journal of pediatric surgery, Vol.46(3), pp.577-584
- Publisher
- Elsevier Inc
- DOI
- 10.1016/j.jpedsurg.2010.12.018
- PMID
- 21376215
- ISSN
- 0022-3468
- eISSN
- 1531-5037
- Language
- English
- Date published
- 03/2011
- Academic Unit
- Stead Family Department of Pediatrics; Surgery
- Record Identifier
- 9984051519002771
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