Journal article
Pembrolizumab Induced Acute Persistent Airway Disease in a Patient with Recurrent Respiratory Papillomatosis (RRP)
Annals of otology, rhinology & laryngology, Vol.131(3), pp.331-336
03/2022
DOI: 10.1177/00034894211021276
PMID: 34056952
Abstract
To present an uncommon but serious, recently identified complication of checkpoint inhibitor therapy in a patient treated with pembrolizumab infusion for disseminated recurrent respiratory papillomatosis (RRP).
Case report.
A 43-year-old woman with underlying asthma developed acute hypoxic respiratory failure within 24 hours of her third infusion of pembrolizumab for treatment of intractable, disseminated recurrent respiratory papillomatosis. Pulmonary function testing revealed a severe intra-thoracic obstructive ventilatory defect. Discontinuation of pembrolizumab, ventilatory support, and treatment with systemic and inhaled corticosteroids resulted in resolution of respiratory failure; however, her underlying asthma remains poorly controlled.
To our knowledge, this case is the first report of pembrolizumab-induced obstructive respiratory failure in a patient being treated for RRP.
Details
- Title: Subtitle
- Pembrolizumab Induced Acute Persistent Airway Disease in a Patient with Recurrent Respiratory Papillomatosis (RRP)
- Creators
- Kathryn Marcus - University of IowaDaniel J Lee - University of Iowa Hospitals and ClinicsJeffrey S Wilson - University of IowaRichard J H Smith - University of IowaMichael Puricelli - University of Iowa Hospitals and Clinics
- Resource Type
- Journal article
- Publication Details
- Annals of otology, rhinology & laryngology, Vol.131(3), pp.331-336
- DOI
- 10.1177/00034894211021276
- PMID
- 34056952
- ISSN
- 0003-4894
- eISSN
- 1943-572X
- Language
- English
- Date published
- 03/2022
- Academic Unit
- Roy J. Carver Department of Biomedical Engineering; Molecular Physiology and Biophysics; Pulmonary, Critical Care, and Occupational Medicine; Anatomy and Cell Biology; Stead Family Department of Pediatrics; Iowa Neuroscience Institute; Otolaryngology; Internal Medicine
- Record Identifier
- 9984256934402771
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