Journal article
Pemphigus vulgaris presenting in a radiation portal
Journal of the American Academy of Dermatology, Vol.56(5), pp.S82-S85
2007
DOI: 10.1016/j.jaad.2006.10.956
PMID: 17434046
Abstract
We report a case of mucocutaneous pemphigus vulgaris in a patient with squamous cell carcinoma of the lung. The cutaneous involvement was limited to the skin within his therapeutic radiation portal. The diagnosis of pemphigus vulgaris was confirmed by histopathology and immunologic studies. Direct immunofluorescence demonstrated IgG and C3 in the intercellular spaces and indirect immunofluorescence was positive on monkey esophagus at a titer of 1:160. Enzyme-linked immunosorbent assay of the patient's serum detected autoantibodies only to desmoglein (Dsg)3, with no reactivity to Dsg1. Immunomapping of perilesional skin from the irradiated field illustrated decreased Dsg1 expression compared with a control sample from an area that was not exposed to radiation. This case provides support for the Dsg compensation hypothesis and may also suggest a mechanism by which irradiation may induce skin lesions.
Details
- Title: Subtitle
- Pemphigus vulgaris presenting in a radiation portal
- Creators
- Amber C Robbins - From the Department of Dermatology, Medical College of WisconsinZelmira Lazarova - From the Department of Dermatology, Medical College of WisconsinMarleen M Janson - From the Department of Dermatology, Medical College of WisconsinJanet A Fairley - From the Department of Dermatology, Medical College of Wisconsin
- Resource Type
- Journal article
- Publication Details
- Journal of the American Academy of Dermatology, Vol.56(5), pp.S82-S85
- DOI
- 10.1016/j.jaad.2006.10.956
- PMID
- 17434046
- NLM abbreviation
- J Am Acad Dermatol
- ISSN
- 0190-9622
- eISSN
- 1097-6787
- Publisher
- Mosby, Inc
- Language
- English
- Date published
- 2007
- Academic Unit
- Dermatology
- Record Identifier
- 9984025427402771
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