Penetrating keratoplasty in congenital hereditary endothelial dystrophy

A A al-Rajhi; M D Wagoner

doi:10.1016/S0161-6420(97)30200-0

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Penetrating keratoplasty in congenital hereditary endothelial dystrophy

Journal article

Peer reviewed

Penetrating keratoplasty in congenital hereditary endothelial dystrophy

A A al-Rajhi and M D Wagoner

Ophthalmology (Rochester, Minn.), Vol.104(6), pp.956-961

06/1997

DOI: 10.1016/S0161-6420(97)30200-0

PMID: 9186436

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Abstract

The purpose of the study is to determine the outcome of penetrating keratoplasty in congenital hereditary endothelial dystrophy. Records of 40 patients (13 males, 27 females) who underwent penetrating keratoplasty (56 eyes) were reviewed. The mean age at surgery was 11.8 years (range, 2 months-35 years). The mean follow-up was 37 months (range, 6-136 months). In 35 (62.5%) of 56 eyes that underwent primary penetrating keratoplasty, the grafts survived. Graft survival analysis showed the probability of obtaining a clear graft is 92% at 1 year, 72% at 2 years, and 56.5% at 5 years. Graft survival was statistically better in eyes where onset of the disease is delayed (P = 0.02), if the graft donor age is between 5 and 30 years versus older than 30 years (P = 0.02), and for patients who kept follow-up appointments versus those who were delinquent (P < 0.03). Visual acuity was 20/40 in 1.9%, 20/50 to 20/80 in 18.9%, 20/100 to 20/300 in 49%, and less than 20/400 in 30.2%. The main causes of graft failure were graft rejection (six eyes) and bacterial keratitis (four eyes). Penetrating keratoplasty in congenital hereditary endothelial dystrophy is moderately successful, and graft survival is better in cases of delayed onset compared with that of congenital onset. Early surgical intervention is recommended to prevent development or progression of amblyopia.

Trabeculectomy

Cornea - surgery

Follow-Up Studies

Humans

Corneal Ulcer - diagnosis

Child, Preschool

Infant

Male

Eye Infections, Bacterial - diagnosis

Eye Infections, Bacterial - microbiology

Keratoplasty, Penetrating

Corneal Ulcer - etiology

Adult

Female

Cornea - pathology

Retrospective Studies

Child

Fuchs' Endothelial Dystrophy - diagnosis

Postoperative Complications

Cornea - microbiology

Fuchs' Endothelial Dystrophy - surgery

Intraocular Pressure

Fuchs' Endothelial Dystrophy - congenital

Graft Rejection - etiology

Graft Survival

Treatment Outcome

Glaucoma - surgery

Graft Rejection - diagnosis

Glaucoma - diagnosis

Visual Acuity

Glaucoma - congenital

Streptococcus pneumoniae

Pedigree

Adolescent

Tissue Donors

Details

Title: Subtitle: Penetrating keratoplasty in congenital hereditary endothelial dystrophy
Creators: A A al-Rajhi - Anterior Segment Division, King Khaled Eye Specialist Hospital, Riyadh, Saudi Arabia
M D Wagoner
Resource Type: Journal article
Publication Details: Ophthalmology (Rochester, Minn.), Vol.104(6), pp.956-961
Publisher: United States
DOI: 10.1016/S0161-6420(97)30200-0
PMID: 9186436
ISSN: 0161-6420
eISSN: 1549-4713
Language: English
Date published: 06/1997
Academic Unit: Ophthalmology and Visual Sciences
Record Identifier: 9983980281202771

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