Penetrating keratoplasty versus deep anterior lamellar keratoplasty for the treatment of keratoconus

Alex W Cohen; Kenneth M Goins; John E Sutphin; George R Wandling; Michael D Wagoner

doi:10.1007/s10792-010-9393-9

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Penetrating keratoplasty versus deep anterior lamellar keratoplasty for the treatment of keratoconus

Journal article

Peer reviewed

Penetrating keratoplasty versus deep anterior lamellar keratoplasty for the treatment of keratoconus

Alex W Cohen, Kenneth M Goins, John E Sutphin, George R Wandling and Michael D Wagoner

International ophthalmology, Vol.30(6), pp.675-681

12/2010

DOI: 10.1007/s10792-010-9393-9

PMID: 20862520

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Abstract

To compare the outcome of penetrating keratoplasty (PKP) and deep anterior lamellar keratoplasty (DALK) in the surgical management of keratoconus (KC). A retrospective review was conducted of the medical records of all patients treated with PKP or DALK for KC at University of Iowa Hospitals and Clinics from January 1, 2000, to December 31, 2006. The main outcome measures were visual outcome, graft survival, and complications. Cases with a minimum follow-up of 6 months were included in the statistical analysis. Of 41 eyes that met the inclusion criteria, 30 eyes were treated with PKP and 11 eyes were treated with DALK. The mean follow-up was almost identical for eyes treated with PKP or DALK (21.9 vs. 22.5 months, respectively). At the most recent examination, the mean best spectacle-corrected visual acuity (BSCVA) was 20/28 for the PKP group and 20/29 for the DALK group (P = 0.77). The percentage of eyes that achieved BSCVA of 20/25 or better was higher in the PKP group than in the DALK group (77.3 vs. 45.5%, respectively), but this difference was not statistically significant (P = 0.72). Endothelial rejection occurred in 4 (13.3%) eyes after PKP. Visually significant interface haze occurred in the early postoperative course in 2 (18.2%) eyes after DALK. No cases of late-onset endothelial failure were found in either group. Treatment of KC with PKP or DALK is associated with similar visual outcomes, graft survival, and prevalence of sight-threatening complications.

Keratoplasty, Penetrating - adverse effects

Postoperative Complications - physiopathology

Corneal Transplantation - methods

Humans

Middle Aged

Graft Survival

Male

Treatment Outcome

Postoperative Complications - epidemiology

Visual Acuity

Eyeglasses

Incidence

Young Adult

Corneal Transplantation - adverse effects

Keratoconus - surgery

Adult

Female

Aged

Keratoconus - physiopathology

Details

Title: Subtitle: Penetrating keratoplasty versus deep anterior lamellar keratoplasty for the treatment of keratoconus
Creators: Alex W Cohen - University of Iowa
Kenneth M Goins
John E Sutphin
George R Wandling
Michael D Wagoner
Resource Type: Journal article
Publication Details: International ophthalmology, Vol.30(6), pp.675-681
Publisher: Netherlands
DOI: 10.1007/s10792-010-9393-9
PMID: 20862520
ISSN: 0165-5701
eISSN: 1573-2630
Language: English
Date published: 12/2010
Academic Unit: Ophthalmology and Visual Sciences
Record Identifier: 9983980061002771

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