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Penicillamine-induced elastosis of the mucosal lip
Journal article

Penicillamine-induced elastosis of the mucosal lip

Bethany K.H Lewis, Peggy L Chern and Mary Seabury Stone
Journal of the American Academy of Dermatology, Vol.60(4), pp.700-703
2009
DOI: 10.1016/j.jaad.2008.09.018
PMID: 19293020

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Abstract

Long-term penicillamine therapy has been associated with alterations in dermal elastic tissue. Well-described associated dermatoses include pseudo-pseudoxanthoma elasticum, acquired cutis laxa, elastosis perforans serpiginosa, and anetoderma. Histologically, “lumpy-bumpy”" or “bramble-bush”" morphologic changes of elastic fibers in the dermis are characteristic. Previous reports of these findings in normal-appearing skin and internal organs suggest a systemic elastolytic process. Here we report an unusual case of penicillamine-induced elastosis affecting the mucosa of the lip with characteristic histologic features.

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