Journal article
Peptide-guided gene delivery
The AAPS journal, Vol.9(1), pp.E18-E29
03/2007
DOI: 10.1208/aapsj0901003
PMCID: PMC2751301
PMID: 17408236
Abstract
Although currently less efficient than their viral counter-parts, nonviral vectors are under intense investigation as a safer alternative for gene therapy. For successful delivery, the nonviral vector must be able to overcome many barriers to protect DNA and specifically deliver it for efficient gene expression in target cells. The use of peptides as gene delivery vectors is advantageous over other nonviral agents in that they are able to achieve all of these goals. This review will focus on the application of peptides to mediate nonviral gene delivery. By examining the literature over the past 20 years, it becomes clear that no other class of biomolecules are simultaneously capable of DNA condensation, blocking metabolism, endosomal escape, nuclear localization, and receptor targeting. Based on virtually limitless diversity of peptide sequence and function information from nature, it is increasingly clear that peptide-guided gene delivery is still in its infancy.
Details
- Title: Subtitle
- Peptide-guided gene delivery
- Creators
- Molly E Martin - Division of Medicinal and Natural Products Chemistry, College of Pharmacy, University of Iowa, 115 S Grand Avenue, 52242 Iowa City, IAKevin G Rice - Division of Medicinal and Natural Products Chemistry, College of Pharmacy, University of Iowa, 115 S Grand Avenue, 52242 Iowa City, IA
- Resource Type
- Journal article
- Publication Details
- The AAPS journal, Vol.9(1), pp.E18-E29
- DOI
- 10.1208/aapsj0901003
- PMID
- 17408236
- PMCID
- PMC2751301
- NLM abbreviation
- AAPS J
- ISSN
- 1550-7416
- eISSN
- 1550-7416
- Publisher
- Springer-Verlag; New York
- Language
- English
- Date published
- 03/2007
- Academic Unit
- Pharmaceutical Sciences and Experimental Therapeutics; Craniofacial Anomalies Research Center; Pharmacy Practice and Science; Medicinal and Natural Products Chemistry
- Record Identifier
- 9984065693602771
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