Journal article
Perceived partner substance use, genetic predispositions, and their associations with problematic alcohol use, emotional well-being, and relationship quality
Psychological medicine, Vol.56, e71
03/24/2026
DOI: 10.1017/S0033291726103237
PMID: 41873527
Abstract
Romantic relationships are important contexts for substance use and emotional well-being. We tested the hypotheses that (i) genetic predispositions for alcohol consumption would be positively associated with partner substance use, (ii) partner substance use would moderate genetic influences on one's own alcohol outcomes, and (iii) partner discordance in substance use would be associated with lower emotional well-being and relationship quality.
Analyses included 2,357 participants (M
= 51.4, 58.2% female) from the Collaborative Studies on the Genetics of Alcoholism. Focal measures included participants' reports of their own and their current partner's past-year substance use (frequencies of alcohol use, heavy drinking, drunkenness, cannabis use, and nicotine use), emotional well-being, and relationship quality. Participants' genetic predispositions were indexed with genome-wide polygenic scores for alcohol consumption (PGS
). Participant-partner substance use discordance was calculated as the difference between the participant's and their partner's use for each substance use measure, separately.
Participant PGS
was not significantly associated with partners' perceived substance use. Frequent perceived partner alcohol use and heavy drinking significantly amplified the association between PGS
and alcohol use or drunkenness. Frequent perceived partner drunkenness and cannabis use significantly attenuated the association between PGS
and heavy drinking or frequency of alcohol use. Participant-partner discordance for several substance use measures was significantly associated with lower emotional well-being and relationship quality, controlling for participant and partner substance use main effects.
The results highlight the importance of partner substance use in etiological models of alcohol use, emotional health outcomes, and relationship quality.
Details
- Title: Subtitle
- Perceived partner substance use, genetic predispositions, and their associations with problematic alcohol use, emotional well-being, and relationship quality
- Creators
- Megan E Cooke - Rutgers, The State University of New JerseySally I-Chun Kuo - Rutgers, The State University of New JerseyErin Lumpe - Rutgers, The State University of New JerseyFazil Aliev - Rutgers, The State University of New JerseySarah J Brislin - Rutgers, The State University of New JerseyKathleen K Bucholz - Washington University in St. LouisGrace Chan - University of IowaDanielle M Dick - Rutgers, The State University of New JerseyHoward J Edenberg - Indiana University – Purdue University IndianapolisChella Kamarajan - SUNY Downstate Health Sciences UniversityJohn Kramer - University of IowaWeipeng Kuang - SUNY Downstate Health Sciences UniversitySamuel Kuperman - University of IowaVivia V McCutcheon - Washington University in St. LouisZoe Neale - SUNY Downstate Health Sciences UniversityMartin H Plawecki - Indiana University School of MedicineBernice Porjesz - SUNY Downstate Health Sciences UniversityJill A Rabinowitz - Rutgers, The State University of New JerseyJessica E Salvatore - Rutgers, The State University of New JerseyCOGA Investigators
- Resource Type
- Journal article
- Publication Details
- Psychological medicine, Vol.56, e71
- DOI
- 10.1017/S0033291726103237
- PMID
- 41873527
- NLM abbreviation
- Psychol Med
- ISSN
- 0033-2917
- eISSN
- 1469-8978
- Publisher
- Cambridge University Press
- Grant note
- R01AA030996 / NIAAA NIH HHS U10AA008401 / NIAAA NIH HHS K23DA058808 / NIDA NIH HHS
- Language
- English
- Date published
- 03/24/2026
- Academic Unit
- Psychiatry
- Record Identifier
- 9985147176902771
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