Percent Emphysema and Daily Motor Activity Levels in the General Population: Multi-Ethnic Study of Atherosclerosis

Christian M Lo Cascio; Mirja Quante; Eric A Hoffman; Alain G Bertoni; Carrie P Aaron; Joseph E Schwartz; Mark V Avdalovic; Vincent S Fan; Gina S Lovasi; Steven M Kawut; John H M Austin; Susan Redline; R Graham Barr

doi:10.1016/j.chest.2016.11.033

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Percent Emphysema and Daily Motor Activity Levels in the General Population: Multi-Ethnic Study of Atherosclerosis

Journal article

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Peer reviewed

Percent Emphysema and Daily Motor Activity Levels in the General Population: Multi-Ethnic Study of Atherosclerosis

Christian M Lo Cascio, Mirja Quante, Eric A Hoffman, Alain G Bertoni, Carrie P Aaron, Joseph E Schwartz, Mark V Avdalovic, Vincent S Fan, Gina S Lovasi, Steven M Kawut, …

Chest, Vol.151(5), pp.1039-1050

05/2017

DOI: 10.1016/j.chest.2016.11.033

PMCID: PMC5472515

PMID: 27940190

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Abstract

COPD is associated with reduced physical capacity. However, it is unclear whether pulmonary emphysema, which can occur without COPD, is associated with reduced physical activity in daily life, particularly among people without COPD and never smokers. We hypothesized that greater percentage of emphysema-like lung on CT scan is associated with reduced physical activity assessed by actigraphy and self-report. The Multi-Ethnic Study of Atherosclerosis (MESA) enrolled participants free of clinical cardiovascular disease from the general population. Percent emphysema was defined as percentage of voxels < -950 Hounsfield units on full-lung CT scans. Physical activity was measured by wrist actigraphy over 7 days and a questionnaire. Multivariable linear regression was used to adjust for age, sex, race/ethnicity, height, weight, education, smoking, pack-years, and lung function. Among 1,435 participants with actigraphy and lung measures, 47% had never smoked, and 8% had COPD. Percent emphysema was associated with lower activity levels on actigraphy (P = .001), corresponding to 1.5 hour less per week of moderately paced walking for the average participant in quintile 2 vs 4 of percent emphysema. This association was significant among participants without COPD (P = .004) and among ever (P = .01) and never smokers (P = .03). It was also independent of coronary artery calcium and left ventricular ejection fraction. There was no evidence that percent emphysema was associated with self-reported activity levels. Percent emphysema was associated with decreased physical activity in daily life objectively assessed by actigraphy in the general population, among participants without COPD, and nonsmokers.

Multivariate Analysis

United States - epidemiology

Prospective Studies

Humans

Middle Aged

Male

Tomography, X-Ray Computed

Lung - diagnostic imaging

Pulmonary Disease, Chronic Obstructive - physiopathology

Pulmonary Disease, Chronic Obstructive - epidemiology

Forced Expiratory Volume

Ethnic Groups

Exercise

Female

Pulmonary Disease, Chronic Obstructive - diagnostic imaging

Surveys and Questionnaires

Severity of Illness Index

Ventricular Dysfunction, Left - epidemiology

Pulmonary Emphysema - physiopathology

Actigraphy

Linear Models

Pulmonary Emphysema - diagnostic imaging

Stroke Volume

Vital Capacity

Smoking - epidemiology

Vascular Calcification - epidemiology

Aged

Coronary Artery Disease - epidemiology

Pulmonary Emphysema - epidemiology

Walk Test

Cohort Studies

Details

Title: Subtitle: Percent Emphysema and Daily Motor Activity Levels in the General Population: Multi-Ethnic Study of Atherosclerosis
Creators: Christian M Lo Cascio - Department of Medicine, Columbia University, New York, NY
Mirja Quante - Department of Medicine, Brigham and Women's Hospital and Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA
Eric A Hoffman - Department of Internal Medicine, University of Iowa, Iowa City, IA
Alain G Bertoni - Department of Epidemiology and Prevention, Wake Forest University, Winston-Salem, NC
Carrie P Aaron - Department of Medicine, Columbia University, New York, NY
Joseph E Schwartz - Department of Medicine, Columbia University, New York, NY; Department of Psychiatry and Behavioral Science, Stony Brook University, Stony Brook, NY
Mark V Avdalovic - Department of Internal Medicine, UC Davis School of Medicine, Sacramento, CA
Vincent S Fan - VA Puget Sound Health Care System, Seattle, WA; Department of Medicine, University of Washington, Seattle, WA
Gina S Lovasi - Department of Medicine, Columbia University, New York, NY
Steven M Kawut - Department of Medicine, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA
John H M Austin - Department of Radiology, Columbia University, New York, NY
Susan Redline - Department of Medicine, Brigham and Women's Hospital and Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA
R Graham Barr - Department of Medicine, Columbia University, New York, NY. Electronic address: rgb9@columbia.edu
Resource Type: Journal article
Publication Details: Chest, Vol.151(5), pp.1039-1050
Publisher: United States
DOI: 10.1016/j.chest.2016.11.033
PMID: 27940190
PMCID: PMC5472515
ISSN: 0012-3692
eISSN: 1931-3543
Grant note: R01 HL098433 / NHLBI NIH HHS P30 ES005605 / NIEHS NIH HHS R01 HL093081 / NHLBI NIH HHS K24 HL103844 / NHLBI NIH HHS R01 HL112986 / NHLBI NIH HHS R01 HL077612 / NHLBI NIH HHS
Language: English
Date published: 05/2017
Academic Unit: Roy J. Carver Department of Biomedical Engineering; Radiology; Internal Medicine
Record Identifier: 9984051761502771

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