Journal article
Percentile scores for the revised University of Pennsylvania Smell Identification Test for 16,972 individuals 60 years of age and older
NPJ Parkinson's Disease, Vol.11(1), 280
10/01/2025
DOI: 10.1038/s41531-025-01095-9
PMCID: PMC12488959
PMID: 41034300
Abstract
The study goal was to use a very large study cohort to establish normative data for the revised UPSIT (UPSIT-R) and to compare the resultant percentiles to those of the original UPSIT. A second study was performed to compare the performance of these two tests in a cohort of persons with and without Parkinson’s disease (PD). UPSIT-R percentiles were derived by age and sex in 16,972 volunteers. Non-parametric statistics were employed to compare the results of those with and without PD. UPSIT-R performance declined with increasing age; deficits were more pronounced in men than women. The magnitude of the difference between the original and revised test percentile scores differed by age and sex. Olfactory deficits in PD were confirmed on the UPSIT-R. This study provides normative data clinically useful for assessing the relative degree of dysfunction in persons 60 years of age and older using the UPSIT-R. Trial Registration Information: ClinicalTrials.gov
NCT05065060
.
Details
- Title: Subtitle
- Percentile scores for the revised University of Pennsylvania Smell Identification Test for 16,972 individuals 60 years of age and older
- Creators
- Kerri A. Pierz - Evidation HealthWhitley Aamodt - University of PennsylvaniaCaroline Gochanour - University of IowaRyan Kurth - University of IowaMichael C. Brumm - University of IowaChristopher S. Coffey - University of IowaLaura E. Heathers - Indiana University – Purdue University IndianapolisMichelle Totten - Indiana University – Purdue University IndianapolisRichard L. Doty - University of PennsylvaniaKenneth Marek - Institute for Neurodegenerative DisordersAndrew Siderowf - University of PennsylvaniaParkinson’s Progression Markers Initiative
- Resource Type
- Journal article
- Publication Details
- NPJ Parkinson's Disease, Vol.11(1), 280
- DOI
- 10.1038/s41531-025-01095-9
- PMID
- 41034300
- PMCID
- PMC12488959
- NLM abbreviation
- NPJ Parkinsons Dis
- ISSN
- 2373-8057
- eISSN
- 2373-8057
- Publisher
- Nature Publishing Group UK
- Grant note
- Michael J. Fox Foundation and funding partners
- Language
- English
- Date published
- 10/01/2025
- Academic Unit
- Biostatistics
- Record Identifier
- 9984969107002771
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