Perceptions of post-transplant recidivism in liver transplantation for alcoholic liver disease

Yoshikuni Kawaguchi; Yasuhiko Sugawara; Nobuhisa Akamatsu; Junichi Kaneko; Tomohiro Tanaka; Sumihito Tamura; Taku Aoki; Yoshihiro Sakamoto; Kiyoshi Hasegawa; Norihiro Kokudo

doi:10.4254/wjh.v6.i11.812

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Perceptions of post-transplant recidivism in liver transplantation for alcoholic liver disease

Journal article

Open access

Peer reviewed

Perceptions of post-transplant recidivism in liver transplantation for alcoholic liver disease

Yoshikuni Kawaguchi, Yasuhiko Sugawara, Nobuhisa Akamatsu, Junichi Kaneko, Tomohiro Tanaka, Sumihito Tamura, Taku Aoki, Yoshihiro Sakamoto, Kiyoshi Hasegawa and Norihiro Kokudo

World journal of hepatology, Vol.6(11), pp.812-817

11/27/2014

DOI: 10.4254/wjh.v6.i11.812

PMCID: PMC4243155

PMID: 25429319

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Abstract

Although alcoholic liver disease (ALD) is regarded as a common indication for liver transplantation (LT), debatable issues exist on the requirement for preceding alcoholic abstinence, appropriate indication criteria, predictive factors for alcoholic recidivism, and outcomes following living-donor LT. In most institutions, an abstinence period of six months before LT has been adopted as a mandatory selection criterion. Data indicating that pre-transplant abstinence is an associated predictive factor for alcoholic recidivism supports the reasoning behind this. However, conclusive evidence about the benefit of adopting an abstinence period is yet to be established. On the other hand, a limited number of reports available on living-donor LT experiences for ALD patients suggest that organ donations from relatives have no suppressive effect on alcoholic recidivism. Prevention of alcoholic recidivism has proved to be the most important treatment after LT based on the resultant inferior long-term outcome of patients. Further evaluations are still needed to establish strategies before and after LT for ALD.

Six-month rule

Abstinence

Alcoholic liver disease

Liver transplantation

Details

Title: Subtitle: Perceptions of post-transplant recidivism in liver transplantation for alcoholic liver disease
Creators: Yoshikuni Kawaguchi - Yoshikuni Kawaguchi, Yasuhiko Sugawara, Nobuhisa Akamatsu, Junichi Kaneko, Sumihito Tamura, Taku Aoki, Yoshihiro Sakamoto, Kiyoshi Hasegawa, Norihiro Kokudo, Artificial Organ and Transplantation Surgery Division, Department of Surgery, Graduate School of Medicine, University of Tokyo, Tokyo 113-0033, Japan
Yasuhiko Sugawara - Yoshikuni Kawaguchi, Yasuhiko Sugawara, Nobuhisa Akamatsu, Junichi Kaneko, Sumihito Tamura, Taku Aoki, Yoshihiro Sakamoto, Kiyoshi Hasegawa, Norihiro Kokudo, Artificial Organ and Transplantation Surgery Division, Department of Surgery, Graduate School of Medicine, University of Tokyo, Tokyo 113-0033, Japan
Nobuhisa Akamatsu - Yoshikuni Kawaguchi, Yasuhiko Sugawara, Nobuhisa Akamatsu, Junichi Kaneko, Sumihito Tamura, Taku Aoki, Yoshihiro Sakamoto, Kiyoshi Hasegawa, Norihiro Kokudo, Artificial Organ and Transplantation Surgery Division, Department of Surgery, Graduate School of Medicine, University of Tokyo, Tokyo 113-0033, Japan
Junichi Kaneko - Yoshikuni Kawaguchi, Yasuhiko Sugawara, Nobuhisa Akamatsu, Junichi Kaneko, Sumihito Tamura, Taku Aoki, Yoshihiro Sakamoto, Kiyoshi Hasegawa, Norihiro Kokudo, Artificial Organ and Transplantation Surgery Division, Department of Surgery, Graduate School of Medicine, University of Tokyo, Tokyo 113-0033, Japan
Tomohiro Tanaka - Yoshikuni Kawaguchi, Yasuhiko Sugawara, Nobuhisa Akamatsu, Junichi Kaneko, Sumihito Tamura, Taku Aoki, Yoshihiro Sakamoto, Kiyoshi Hasegawa, Norihiro Kokudo, Artificial Organ and Transplantation Surgery Division, Department of Surgery, Graduate School of Medicine, University of Tokyo, Tokyo 113-0033, Japan
Sumihito Tamura - Yoshikuni Kawaguchi, Yasuhiko Sugawara, Nobuhisa Akamatsu, Junichi Kaneko, Sumihito Tamura, Taku Aoki, Yoshihiro Sakamoto, Kiyoshi Hasegawa, Norihiro Kokudo, Artificial Organ and Transplantation Surgery Division, Department of Surgery, Graduate School of Medicine, University of Tokyo, Tokyo 113-0033, Japan
Taku Aoki - Yoshikuni Kawaguchi, Yasuhiko Sugawara, Nobuhisa Akamatsu, Junichi Kaneko, Sumihito Tamura, Taku Aoki, Yoshihiro Sakamoto, Kiyoshi Hasegawa, Norihiro Kokudo, Artificial Organ and Transplantation Surgery Division, Department of Surgery, Graduate School of Medicine, University of Tokyo, Tokyo 113-0033, Japan
Yoshihiro Sakamoto - Yoshikuni Kawaguchi, Yasuhiko Sugawara, Nobuhisa Akamatsu, Junichi Kaneko, Sumihito Tamura, Taku Aoki, Yoshihiro Sakamoto, Kiyoshi Hasegawa, Norihiro Kokudo, Artificial Organ and Transplantation Surgery Division, Department of Surgery, Graduate School of Medicine, University of Tokyo, Tokyo 113-0033, Japan
Kiyoshi Hasegawa - Yoshikuni Kawaguchi, Yasuhiko Sugawara, Nobuhisa Akamatsu, Junichi Kaneko, Sumihito Tamura, Taku Aoki, Yoshihiro Sakamoto, Kiyoshi Hasegawa, Norihiro Kokudo, Artificial Organ and Transplantation Surgery Division, Department of Surgery, Graduate School of Medicine, University of Tokyo, Tokyo 113-0033, Japan
Norihiro Kokudo - Yoshikuni Kawaguchi, Yasuhiko Sugawara, Nobuhisa Akamatsu, Junichi Kaneko, Sumihito Tamura, Taku Aoki, Yoshihiro Sakamoto, Kiyoshi Hasegawa, Norihiro Kokudo, Artificial Organ and Transplantation Surgery Division, Department of Surgery, Graduate School of Medicine, University of Tokyo, Tokyo 113-0033, Japan
Resource Type: Journal article
Publication Details: World journal of hepatology, Vol.6(11), pp.812-817
DOI: 10.4254/wjh.v6.i11.812
PMID: 25429319
PMCID: PMC4243155
NLM abbreviation: World J Hepatol
ISSN: 1948-5182
eISSN: 1948-5182
Language: English
Date published: 11/27/2014
Academic Unit: Gastroenterology and Hepatology; Internal Medicine
Record Identifier: 9984094542602771

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