Journal article
Percutaneous Image-guided Core Needle Biopsy for Upper Tract Urothelial Carcinoma
Urology (Ridgewood, N.J.), Vol.135, pp.95-100
01/2020
DOI: 10.1016/j.urology.2019.10.005
PMID: 31655078
Abstract
To better understand the safety and diagnostic yield of percutaneous core-needle biopsy (PCNB) for upper tract urothelial carcinoma (UTUC).
Of 444 patients undergoing radical nephroureterectomy (RNU) for UTUC between 2009 and 2017 at our institution, 42 who had PCNB prior to RNU were identified for analysis. Endpoints included safety, diagnostic yield, and concordance with RNU pathology. PCNB specimens were deemed histologically concordant with RNU specimens for cases when cytologic evaluation of biopsy specimen and corresponding pathologic evaluation of RNU specimen both made a histologic diagnosis of urothelial carcinoma.
Median tumor size was 3.8 cm (1.2-10.2 cm). All lesions arose from the pelvicalyceal system. CT-guidance was utilized in 52% (n = 22), and ultrasound-guidance in 48% (n = 20). Relative to RNU pathology, 95% of PCNBs demonstrated histologic concordance. Histologic grade was provided in 69% (n = 29) of PCNBs, with a 90% (n = 26) concordance with surgical pathology. Grades 1-2 and 3 complications occurred in 14.3% (n = 6) and 2.4% (n = 1), respectively. At a median follow-up of 28.2 months (range, 1.2-97.1 months) after biopsy, no cases of radiographic tract seeding were identified.
In our cohort of 42 patients undergoing RNU for UTUC, PCNB appeared a safe diagnostic tool with high histologic yield and grade concordance. With greater than 2 years of follow-up, no cases of tract seeding were identified.
Details
- Title: Subtitle
- Percutaneous Image-guided Core Needle Biopsy for Upper Tract Urothelial Carcinoma
- Creators
- Jason P Joseph - Department of Urology Mayo Clinic Rochester MNTheodora A Potretzke - Mayo ClinicVignesh Packiam - Mayo ClinicVidit Sharma - Department of Urology Mayo Clinic Rochester MNAmir Toussi - Department of Urology Mayo Clinic Rochester MNTanner S Miest - Department of Urology Mayo Clinic Rochester MNTristan Juvet - Department of Urology Mayo Clinic Rochester MNStephen A Boorjian - Department of Urology Mayo Clinic Rochester MNR Houston Thompson - Department of Urology Mayo Clinic Rochester MNChristopher L Welle - Mayo ClinicThomas D Atwell - Mayo ClinicBradley C Leibovich - Department of Urology Mayo Clinic Rochester MNMatthew K Tollefson - Department of Urology Mayo Clinic Rochester MNAaron M Potretzke - Department of Urology, Mayo Clinic, Rochester, MN. Electronic address: Potretzke.Aaron@mayo.edu.
- Resource Type
- Journal article
- Publication Details
- Urology (Ridgewood, N.J.), Vol.135, pp.95-100
- DOI
- 10.1016/j.urology.2019.10.005
- PMID
- 31655078
- ISSN
- 0090-4295
- eISSN
- 1527-9995
- Language
- English
- Date published
- 01/2020
- Academic Unit
- Urology
- Record Identifier
- 9984319993402771
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