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Perforating collagenosis
Journal article   Open access   Peer reviewed

Perforating collagenosis

Molly Yancovitz, Hillary Johnson, Nadia Wang and Miriam K Pomeranz
Dermatology online journal, Vol.14(10), pp.14-14
10/15/2008
DOI: 10.5070/D34xx1z8t7
PMID: 19061613
url
https://doi.org/10.5070/D34xx1z8t7View
Published (Version of record) Open Access

Abstract

A 55-year-old man presented with a three-week history of pruritic, erythematous papules with hyperkeratotic dells on the dorsum of the left hand, which was preceded by swelling, redness and itching. Histopathologic examination showed an acanthotic epidermis with a central invagination filled with a plug composed of parakeratotic debris, collagen, and inflammatory cells. These findings are consistent with acquired reactive perforating collagenosis, which is most frequently reported in patients with pruritus and underlying diabetes mellitus or chronic renal insufficiency. Topical and oral retinoids and topical and intralesional glucocorticoids have been reported to be effective in some patients in case series.
 Epidermis - pathology Humans Middle Aged Male Keratosis - diagnosis Edema - etiology Hand Dermatoses - pathology Melanosis - etiology Collagen Diseases - diagnosis Pruritus - etiology Collagen Diseases - pathology Hand Dermatoses - diagnosis Keratosis - pathology Diabetes Mellitus, Type 2 - complications

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