Journal article
Performance Characteristics of Serologic Tests for Human Immunodeficiency Virus Type 1 (HIV-1) Antibody among Minnesota Blood Donors: Public Health and Clinical Implications
Annals of internal medicine, Vol.110(8), pp.617-621
04/15/1989
DOI: 10.7326/0003-4819-110-8-617
PMID: 2648922
Abstract
Study objective: To evaluate performance characteristics of sequential enzyme immunoassay (EIA) and Western blot human immunodeficiency virus type 1 (HIV-1) antibody testing in a low-risk population.
Design: Three-year prospective study of a selected sample from a community-based population.
Setting: Two blood collection facilities in Minnesota.
Population: Minnesota blood donors.
Results: During the study period, 630,190 units of blood (donations) from an estimated 290,110 Minnesota-resident donors were screened for HIV-1 antibody. Seventeen Minnesota-resident donors were identified as positive for HIV-1 antibody. Sixteen donors were available for follow-up HIV-1 culture: all were culture positive. The other donor, who was not available for follow-up culture, was likely infected with HIV-1 based on a history of high-risk behavior and positive serologic findings for hepatitis B surface antigen. Using 95% binomial confidence intervals, performance characteristics for sequential EIA and Western blot HIV-1 antibody serology were as follows: false-positive rate by number of donations, 0% to 0.0006%; specificity by number of donations, 99.9994% to 100%; predictive value of a positive test, 81% to 100%.
Conclusions: In this low-risk population, the false-positive rate of serologic tests for HIV-1 antibody, using HIV-1 culture as the definitive standard for infection status, was extremely low and test specificity was extremely high.
Details
- Title: Subtitle
- Performance Characteristics of Serologic Tests for Human Immunodeficiency Virus Type 1 (HIV-1) Antibody among Minnesota Blood Donors: Public Health and Clinical Implications
- Creators
- Kristine L MacDonaldJ Brooks Jackson - University of Iowa, PathologyRobert J BowmanHerbert F PoleskyFrank S RhameHenry H Balfour JrMichael T Osterholm
- Resource Type
- Journal article
- Publication Details
- Annals of internal medicine, Vol.110(8), pp.617-621
- DOI
- 10.7326/0003-4819-110-8-617
- PMID
- 2648922
- ISSN
- 0003-4819
- eISSN
- 1539-3704
- Language
- English
- Date published
- 04/15/1989
- Academic Unit
- Pathology; VPMA - Administration
- Record Identifier
- 9984047892102771
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