Journal article
Performance of Platelet Mass Index as a Marker of Severity for Sepsis and Septic Shock in Children
Journal of pediatric intensive care, Vol.12(3), pp.228-234
2023
DOI: 10.1055/s-0041-1731434
PMCID: PMC10411082
PMID: 37565022
Abstract
Abstract
Platelet mass index (PMI) as a prognostic indicator in pediatric sepsis is not reported. In this retrospective observational study, we evaluated PMI's performance as a prognostic indicator in children aged younger than 18 years with sepsis and septic shock in relationship with survival. Over 5 years, we collected data of 122 children admitted to our pediatric intensive care unit (PICU). PMI accuracy was assessed with sensitivity and specificity and its discrimination was assessed using the area under the receiver operating characteristic curve (AUC). The median PMI values on days 1 and 3 of PICU admission were lower among nonsurvivors. On day 1 of PICU admission, a cutoff PMI value of 1,450 fL/nL resulted in a sensitivity of 72% and a specificity of 69%, and the AUC was 0.70 (95% confidence interval [CI]: 0.55–0.86). Similarly, on day 3, a cutoff of 900 fL/nL resulted in a sensitivity of 71% and a specificity of 70%, and the AUC was 0.76 (95% CI: 0.59–0.92). Our exploratory study suggests that low PMI in children with septic shock is associated with increased mortality. Considering the PMI's fair performance, further studies have to assess its clinical value.
Details
- Title: Subtitle
- Performance of Platelet Mass Index as a Marker of Severity for Sepsis and Septic Shock in Children
- Creators
- Madhuradhar Chegondi - Roy J. and Lucille A. Carver College of MedicineNiranjan Vijayakumar - University of IowaRamya Deepthi Billa - University of IowaAditya Badheka - Roy J. and Lucille A. Carver College of MedicineOliver Karam - Children's Hospital of Richmond at VCU
- Resource Type
- Journal article
- Publication Details
- Journal of pediatric intensive care, Vol.12(3), pp.228-234
- Publisher
- Georg Thieme Verlag KG
- DOI
- 10.1055/s-0041-1731434
- PMID
- 37565022
- PMCID
- PMC10411082
- ISSN
- 2146-4618
- eISSN
- 2146-4626
- Language
- English
- Electronic publication date
- 06/22/2021
- Date published
- 2023
- Academic Unit
- Critical Care; Stead Family Department of Pediatrics
- Record Identifier
- 9984354401202771
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