Performance of the 12-item WHODAS 2.0 in prodromal Huntington disease

Ji-In Kim; Jeffrey D Long; James A Mills; Nancy Downing; Janet K Williams; Jane S Paulsen; PREDICT-HD Investigators and Coordinators of the Huntington Study Group

doi:10.1038/ejhg.2015.11

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Performance of the 12-item WHODAS 2.0 in prodromal Huntington disease

Journal article

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Peer reviewed

Performance of the 12-item WHODAS 2.0 in prodromal Huntington disease

Ji-In Kim, Jeffrey D Long, James A Mills, Nancy Downing, Janet K Williams, Jane S Paulsen and PREDICT-HD Investigators and Coordinators of the Huntington Study Group

European journal of human genetics : EJHG, Vol.23(11), pp.1584-1587

11/2015

DOI: 10.1038/ejhg.2015.11

PMCID: PMC4613468

PMID: 25735480

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Abstract

The Diagnostic and Statistical Manual for Mental Disorders, Fifth Edition (DSM-5), recommends the World Health Organization Disability Assessment Schedule (WHODAS) 2.0 for routine clinical use. We tested the utility of the 12-item WHODAS 2.0 in prodromal Huntington disease. Using data from 726 participants and 630 companions over a 3-year follow-up, linear mixed models were fitted to test (1) baseline and longitudinal differences by progression group; (2) participant and companion differences within each group; and (3) sensitivity of the 12-item WHODAS in comparison to the 36-item WHODAS and the Total Functional Capacity (TFC) score from the Unified Huntington's Disease Rating Scale. Participants showed baseline group differences whereas companions showed baseline and longitudinal group differences. Companions reported worse functional decline over time than participants as the disease progresses. The 12-item WHODAS detected longitudinal change better than the 36-item WHODAS and the TFC in the medium progression group. Results suggest the 12-item WHODAS 2.0 can detect baseline and longitudinal differences in prodromal HD and may be useful in HD clinical trials.

Huntington Disease - therapy

Huntington Disease - rehabilitation

Huntington Disease - epidemiology

World Health Organization

Humans

Huntington Disease - physiopathology

Details

Title: Subtitle: Performance of the 12-item WHODAS 2.0 in prodromal Huntington disease
Creators: Ji-In Kim - Department of Psychiatry, Carver College of Medicine, The University of Iowa, Iowa City, IA, USA
Jeffrey D Long - Department of Biostatistics, College of Public Health, The University of Iowa, Iowa City, IA, USA
James A Mills - Department of Psychiatry, Carver College of Medicine, The University of Iowa, Iowa City, IA, USA
Nancy Downing - College of Nursing, The University of Iowa, Iowa City, IA, USA
Janet K Williams - College of Nursing, The University of Iowa, Iowa City, IA, USA
Jane S Paulsen - Department of Psychology, The University of Iowa, Iowa City, IA, USA
PREDICT-HD Investigators and Coordinators of the Huntington Study Group
Contributors: Hans J Johnson (Contributor) - University of Iowa, Electrical and Computer Engineering
Resource Type: Journal article
Publication Details: European journal of human genetics : EJHG, Vol.23(11), pp.1584-1587
DOI: 10.1038/ejhg.2015.11
PMID: 25735480
PMCID: PMC4613468
NLM abbreviation: Eur J Hum Genet
ISSN: 1018-4813
eISSN: 1476-5438
Publisher: England
Grant note: 1U01NS082083 / NINDS NIH HHS 1U01NS082085 / NINDS NIH HHS R01 NS040068 / NINDS NIH HHS 5R01NS040068 / NINDS NIH HHS 1U01NS082086 / NINDS NIH HHS 2 UL1 TR000442-06 / NCATS NIH HHS 5R01NS054893 / NINDS NIH HHS UL1 TR000442 / NCATS NIH HHS
Language: English
Date published: 11/2015
Academic Unit: Roy J. Carver Department of Biomedical Engineering; Electrical and Computer Engineering; Psychiatry; Psychological and Brain Sciences; Biostatistics; Nursing; The Iowa Institute for Biomedical Imaging; The Iowa Initiative for Artificial Intelligence; Iowa Informatics Initiative
Record Identifier: 9984064154802771

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