Journal article
Performance of the postwash total motile sperm count as a predictor of pregnancy at the time of intrauterine insemination: A meta-analysis
Fertility and sterility, Vol.82(3), pp.612-620
2004
DOI: 10.1016/j.fertnstert.2004.01.042
PMID: 15374704
Abstract
To assess the performance and clinical value of the postwash total motile sperm count (postwash TMC) as a test to predict intrauterine insemination (IUI) outcome.
Meta-analysis of diagnostic tests.
Tertiary fertility center.
Patients undergoing IUI.
None.
We detected 16 studies that reported on postwash TMC at insemination and IUI outcome. Summary receiver operating characteristics (ROC) curves indicated a reasonable predictive performance toward IUI outcome, and, at cut-off levels between 0.8 to 5 million motile spermatozoa, the postwash TMC provided a substantial discriminative performance. At these cut-off levels, the specificity of the postwash TMC, defined as the ability to predict failure to become pregnant, was as high as 100%; the sensitivity of the test, defined as the ability to predict pregnancy, was limited.
The postwash TMC at insemination could potentially be used in counseling patients for either IUI or IVF. However, to enable patient counseling before the start of treatment, further studies are needed to establish the accuracy of a postwash TMC during the fertility workup rather than at insemination.
Details
- Title: Subtitle
- Performance of the postwash total motile sperm count as a predictor of pregnancy at the time of intrauterine insemination: A meta-analysis
- Creators
- Janne-Meije van Weert - Center for Reproductive Medicine, Division of Obstetrics and Gynecology, Academic Medical Center, Amsterdam, The NetherlandsSjoerd Repping - Center for Reproductive Medicine, Division of Obstetrics and Gynecology, Academic Medical Center, Amsterdam, The NetherlandsBradley J Van Voorhis - University of Iowa, Obstetrics and GynecologyFulco van der Veen - Center for Reproductive Medicine, Division of Obstetrics and Gynecology, Academic Medical Center, Amsterdam, The NetherlandsPatrick M.M Bossuyt - Department of Clinical Epidemiology, Academic Medical Center, Amsterdam, The NetherlandsBen W.J Mol - Center for Reproductive Medicine, Division of Obstetrics and Gynecology, Academic Medical Center, Amsterdam, The Netherlands
- Resource Type
- Journal article
- Publication Details
- Fertility and sterility, Vol.82(3), pp.612-620
- Publisher
- Elsevier Inc
- DOI
- 10.1016/j.fertnstert.2004.01.042
- PMID
- 15374704
- ISSN
- 0015-0282
- eISSN
- 1556-5653
- Language
- English
- Date published
- 2004
- Academic Unit
- Obstetrics and Gynecology
- Record Identifier
- 9983557124502771
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