Journal article
Perfusion computed tomography in renal cell carcinoma
World journal of radiology, Vol.7(7), pp.170-179
07/28/2015
DOI: 10.4329/wjr.v7.i7.170
PMCID: PMC4506935
PMID: 26217456
Abstract
Various imaging modalities are available for the diagnosis, staging and response evaluation of patients with renal cell carcinoma (RCC). While contrast enhanced computed tomography (CT) is used as the standard of imaging assessment in RCC, a new functional imaging technique like perfusion CT (pCT), goes down to the molecular level and provides new perspectives in imaging of RCC. pCT depicts regional tumor perfusion and vascular permeability which are indirect parameters of tumor angiogenesis and thereby provides vital information regarding tumor microenvironment. Also response evaluation using pCT may predate the size criteria used in Response Evaluation Criteria in Solid Tumors, as changes in the perfusion occurs earlier following tissue kinase inhibitors before any actual change in size. This may potentially help in predicting prognosis, better selection of therapy and more accurate and better response evaluation in patients with RCC. This article describes the techniques and role of pCT in staging and response assessment in patients with RCCs.
Details
- Title: Subtitle
- Perfusion computed tomography in renal cell carcinoma
- Creators
- Chandan J. Das - All India Institute of Medical SciencesUsha Thingujam - All India Inst Med Sci, Dept Radiol, Room 63, New Delhi 110029, IndiaAnanya Panda - All India Institute of Medical SciencesSanjay Sharma - All India Inst Med Sci, Dept Radiol, Room 63, New Delhi 110029, IndiaArun Kumar Gupta - All India Institute of Medical Sciences
- Resource Type
- Journal article
- Publication Details
- World journal of radiology, Vol.7(7), pp.170-179
- Publisher
- Baishideng Publishing Group Inc
- DOI
- 10.4329/wjr.v7.i7.170
- PMID
- 26217456
- PMCID
- PMC4506935
- ISSN
- 1949-8470
- eISSN
- 1949-8470
- Number of pages
- 10
- Language
- English
- Date published
- 07/28/2015
- Academic Unit
- Radiology
- Record Identifier
- 9984700240402771
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