Journal article
Pericardial effusion after pediatric hematopoietic cell transplant
Pediatric transplantation, Vol.17(3), pp.294-299
05/2013
DOI: 10.1111/petr.12062
PMID: 23464863
Abstract
PE can occur following HCT. However, the incidence, etiology, risk factors, and treatment remain unclear. We performed a retrospective study evaluating 355 pediatric recipients of HCT treated at a single institution between January 2005 and August 2010. No cases of PE were identified in the autologous HCT (auto‐HCT) recipients (0/43), while 19% (57/296) of allogeneic HCT (allo‐HCT) developed PE. Among the 57 PE patients, 40 (70%) were males; the median age at transplantation was 6.6 yr (0.1–17.3 yr). Thirty‐six patients (63%) had significant PE with 23 patients (40%) treated by pericardiocentesis, and 19 (33%) experiencing recurrent PE. OS rates for patients who developed PE were 84% at 100 days and 65% at three yr after HCT. Risk factors associated with PE on multivariate analysis included myeloablative conditioning (p = 0.01), delayed neutrophil engraftment (p < 0.01), and CMV + serostatus of the recipient (p = 0.03). Recipients with non‐malignant diseases were significantly less likely to die after development of PE (p = 0.02 and 0.004 when comparing with standard and high‐risk diseases, respectively). In summary, PE is a common and significant complication of pediatric allo‐HCT. Prospective studies are needed to better determine the etiology and optimal method of PE treatment after HCT.
Details
- Title: Subtitle
- Pericardial effusion after pediatric hematopoietic cell transplant
- Creators
- Osamah Aldoss - University of Minnesota Amplatz Children's HospitalDaniel H Gruenstein - University of Minnesota Amplatz Children's HospitalJohn L Bass - University of Minnesota Amplatz Children's HospitalJulia Steinberger - University of Minnesota Amplatz Children's HospitalYan Zhang - University of MinnesotaTodd E DeFor - University of MinnesotaJakub Tolar - University of Minnesota Amplatz Children's HospitalMichael R Verneris - University of Minnesota Amplatz Children's HospitalPaul J Orchard - University of Minnesota Amplatz Children's Hospital
- Resource Type
- Journal article
- Publication Details
- Pediatric transplantation, Vol.17(3), pp.294-299
- DOI
- 10.1111/petr.12062
- PMID
- 23464863
- ISSN
- 1397-3142
- eISSN
- 1399-3046
- Number of pages
- 6
- Language
- English
- Date published
- 05/2013
- Academic Unit
- Stead Family Department of Pediatrics
- Record Identifier
- 9984093337502771
Metrics
19 Record Views