Periconceptional consumption of vitamins containing folic acid and risk for multiple congenital anomalies

Rebecca H Bitsko; Jennita Reefhuis; Paul A Romitti; Cynthia A Moore; Margaret A Honein

doi:10.1002/ajmg.a.31950

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Periconceptional consumption of vitamins containing folic acid and risk for multiple congenital anomalies

Journal article

Peer reviewed

Periconceptional consumption of vitamins containing folic acid and risk for multiple congenital anomalies

Rebecca H Bitsko, Jennita Reefhuis, Paul A Romitti, Cynthia A Moore and Margaret A Honein

American journal of medical genetics. Part A, Vol.143A(20), pp.2397-2405

10/15/2007

DOI: 10.1002/ajmg.a.31950

PMID: 17853468

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Abstract

Although it has been well established that periconceptional use of multivitamins containing folic acid (FA) reduces the risk for neural tube defects, two recent U.S. studies have shown an increased risk for multiple congenital anomalies (MCAs) associated with periconceptional use of vitamins containing FA. This study assessed the association between the periconceptional use of vitamins containing FA and MCAs in a third U.S. population. Mothers of infants with MCAs and a random sample of live births (control infants) born in Iowa during 1993-1995 were eligible to participate in the Birth Defects Risk Factor Surveillance case-control study. During a telephone interview, participants reported on exposure to FA through vitamins, cereal, and food supplements. There was no association between taking vitamins containing FA during the periconceptional period (3 months before conception through the first trimester) and MCAs in the crude estimates or after adjusting for maternal race or ethnicity, education, gravidity, smoking, or alcohol use in the first trimester, or body mass index prior to pregnancy [adjusted odds ratio (aOR)=1.12, 95% confidence interval (CI) 0.75-1.69]. There was also no association between vitamin exposure beginning in the first trimester and MCAs outcome (aOR=1.05, 95% CI 0.59-1.87). In contrast to the two recently published reports, there was no association between periconceptional vitamin exposure and MCAs in the Iowa population.

Vitamin B Complex - adverse effects

Folic Acid - therapeutic use

Folic Acid - adverse effects

Vitamin B Complex - therapeutic use

Humans

Risk Factors

Abnormalities, Multiple - prevention & control

Male

Case-Control Studies

Pregnancy

Abnormalities, Multiple - epidemiology

Adult

Female

Infant, Newborn

Preconception Care

Details

Title: Subtitle: Periconceptional consumption of vitamins containing folic acid and risk for multiple congenital anomalies
Creators: Rebecca H Bitsko - Epidemic Intelligence Service, Office of Workforce and Career Development, Centers for Disease Control and Prevention, Atlanta, Georgia 30333, USA. dvk2@cdc.gov
Jennita Reefhuis
Paul A Romitti
Cynthia A Moore
Margaret A Honein
Resource Type: Journal article
Publication Details: American journal of medical genetics. Part A, Vol.143A(20), pp.2397-2405
Publisher: United States
DOI: 10.1002/ajmg.a.31950
PMID: 17853468
ISSN: 1552-4825
eISSN: 1552-4833
Language: English
Date published: 10/15/2007
Academic Unit: Epidemiology; Biostatistics
Record Identifier: 9983996196602771

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