Periconceptional use of vitamin A and the risk of giving birth to a child with nonsyndromic orofacial clefts-A meta-analysis

Azeez Alade; Wesam Ismail; Rajeshwari Nair; Marin Schweizer; Waheed Awotoye; Abimbola Oladayo; Kelli Ryckman; Azeez Butali

doi:10.1002/bdr2.2005

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Periconceptional use of vitamin A and the risk of giving birth to a child with nonsyndromic orofacial clefts-A meta-analysis

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Periconceptional use of vitamin A and the risk of giving birth to a child with nonsyndromic orofacial clefts-A meta-analysis

Azeez Alade, Wesam Ismail, Rajeshwari Nair, Marin Schweizer, Waheed Awotoye, Abimbola Oladayo, Kelli Ryckman and Azeez Butali

Birth defects research, Vol.114(10), pp.467-477

03/31/2022

DOI: 10.1002/bdr2.2005

PMCID: PMC9321711

PMID: 35357092

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Abstract

We conducted a meta-analysis of observational epidemiological studies to evaluate the association between periconceptional use of vitamin A and the risk of giving birth to a child with nonsyndromic orofacial clefts (NSOFCs). We carried out a systematic literature search of Embase, PubMed, Web of Science, Google Scholar, and OpenGrey from inception to June 30, 2021. Two reviewers independently evaluated the studies that met the inclusion criteria and filled out an abstraction form for each study. Study quality was assessed using the Newcastle-Ottawa Assessment Scale (NOS). Adjusted estimates were pooled with an inverse variance weighting using a random-effects model. Heterogeneity and publication bias were assessed using the Cochran's Q test and funnel plot, respectively. A total of six case-control studies with moderate risk of bias were included. The pooled OR showed a 20% reduction in the risk of NSOFCs for periconceptional use of vitamin A which was not statistically significant (OR = .80; 95% CI .54-1.17, p = .25). For nonsyndromic cleft lip with or without cleft palate (NSCL/P), the studies were homogenous, and the pooled estimate showed a 13% risk reduction, which was significant (OR = .87; 95% CI .77-.99, p = .03). For nonsyndromic cleft palate only (NSCPO), the pooled estimate showed a 33% lower likelihood, which was not statistically significant (OR = .67; 95% CI .42-1.08, p = .10). Our results suggest a possible protective effect for the periconceptional use of vitamin A on the risk of NSCL/P. This finding should be investigated further in prospective studies across multiple populations.

retinol

orofacial clefts

multivitamins

craniofacial birth defects

vitamin A

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Details

Title: Subtitle: Periconceptional use of vitamin A and the risk of giving birth to a child with nonsyndromic orofacial clefts-A meta-analysis
Creators: Azeez Alade - Iowa Institute of Oral Health Research, University of Iowa, Iowa City, Iowa, USA
Wesam Ismail - College of Pharmacy, University of Iowa, Iowa City, Iowa, USA
Rajeshwari Nair - Iowa City VA Health Care System
Marin Schweizer - Iowa City VA Health Care System
Waheed Awotoye - University of Iowa
Abimbola Oladayo - Iowa Institute of Oral Health Research, University of Iowa, Iowa City, Iowa, USA
Kelli Ryckman - University of Iowa
Azeez Butali - University of Iowa
Resource Type: Journal article
Publication Details: Birth defects research, Vol.114(10), pp.467-477
DOI: 10.1002/bdr2.2005
PMID: 35357092
PMCID: PMC9321711
NLM abbreviation: Birth Defects Res
eISSN: 2472-1727
Publisher: Wiley
Language: English
Date published: 03/31/2022
Academic Unit: Oral Pathology, Radiology and Medicine; Stead Family Department of Pediatrics; Epidemiology; Craniofacial Anomalies Research Center; Dental Research; General Internal Medicine; Internal Medicine
Record Identifier: 9984230623802771

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