Perimetry, retinal nerve fiber layer thickness and papilledema grade after cerebrospinal fluid shunting in patients with idiopathic intracranial hypertension

Jennifer L Rizzo; Khoa V Lam; Michael Wall; Machelle D Wilson; John L Keltner

doi:10.1097/WNO.0000000000000181

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Perimetry, retinal nerve fiber layer thickness and papilledema grade after cerebrospinal fluid shunting in patients with idiopathic intracranial hypertension

Journal article

Open access

Peer reviewed

Perimetry, retinal nerve fiber layer thickness and papilledema grade after cerebrospinal fluid shunting in patients with idiopathic intracranial hypertension

Jennifer L Rizzo, Khoa V Lam, Michael Wall, Machelle D Wilson and John L Keltner

Journal of neuro-ophthalmology, Vol.35(1), pp.22-25

03/2015

DOI: 10.1097/WNO.0000000000000181

PMCID: PMC5017247

PMID: 25295682

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Abstract

To investigate the effect of cerebrospinal fluid (CSF) shunting on quantitative perimetry and papilledema in patients with uncontrolled idiopathic intracranial hypertension (IIH). We retrospectively reviewed all cases of IIH with CSF shunting at our institution between 2004 and 2011. Perimetry was performed before and after surgery in 15 patients, and the mean deviation (MD) was compared before and after surgery to assess the effect of the intervention. Fourteen of the IIH patients were female and 1 was male. The average age was 34 years. CSF shunting resulted in significant improvement in the perimetric results with an increase in the MD of 5.63 ± 1.19 dB (P < 0.0001). Additionally, average retinal nerve fiber layer (RNFL) thickness measurement by optical coherence tomography decreased by 87.27 ± 16.65 μm (P < 0.0001), and Frisen papilledema grade decreased by 2.19 ± 0.71 (P < 0.0001). Our results suggest that CSF shunting results in improvement in perimetry, RNFL swelling, and papilledema grade in patients with IIH.

Nerve Fibers - pathology

Visual Field Tests - methods

Vision Disorders - surgery

Humans

Middle Aged

Male

Treatment Outcome

Young Adult

Pseudotumor Cerebri - surgery

Cerebrospinal Fluid Shunts - methods

Adolescent

Pseudotumor Cerebri - complications

Adult

Female

Aged

Papilledema - surgery

Retrospective Studies

Retina - pathology

Papilledema - etiology

Vision Disorders - etiology

Details

Title: Subtitle: Perimetry, retinal nerve fiber layer thickness and papilledema grade after cerebrospinal fluid shunting in patients with idiopathic intracranial hypertension
Creators: Jennifer L Rizzo - University of California Davis Medical Center
Khoa V Lam
Michael Wall
Machelle D Wilson
John L Keltner
Resource Type: Journal article
Publication Details: Journal of neuro-ophthalmology, Vol.35(1), pp.22-25
DOI: 10.1097/WNO.0000000000000181
PMID: 25295682
PMCID: PMC5017247
NLM abbreviation: J Neuroophthalmol
ISSN: 1070-8022
eISSN: 1536-5166
Publisher: United States
Grant note: UL1 TR000002 / NCATS NIH HHS
Language: English
Date published: 03/2015
Academic Unit: Neurology; Ophthalmology and Visual Sciences
Record Identifier: 9983980064102771

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