Perinatal transmission and maternal risks of human papillomavirus infection

E M Smith; S R Johnson; T Cripe; S Perlman; G McGuinness; D Jiang; L Cripe; L P Turek

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Journal article

Perinatal transmission and maternal risks of human papillomavirus infection

E M Smith, S R Johnson, T Cripe, S Perlman, G McGuinness, D Jiang, L Cripe and L P Turek

Cancer detection and prevention, Vol.19(2), pp.196-205

1995

PMID: 7750107

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Abstract

We conducted a prospective study to investigate whether human papillomavirus (HPV) could be vertically transmitted to neonates. Pregnant women (N = 203) were tested for HPV DNA infection during the third trimester and again during labor prior to delivery. Their newborns (N = 203) were tested 1 to 3 days after delivery. Among the mothers, 12.3% (N = 25/203) typed HPV positive at either or both maternal specimen collection periods, whereas only 1.0% of the neonates (N = 2/203) typed positive. This low transmission rate may be due in part to the fact that 65% of mothers who were HPV positive during the third trimester tested HPV negative by labor/delivery. The higher frequency of risks associated with maternal HPV infection were similar to those found in studies of cervical dysplasia and cancer: younger age at first intercourse and first pregnancy, number of sexual partners, and longer duration in use of oral contraceptives. In addition, those who were past smokers and had a shorter recency and latency period in smoking were more likely to be detected with HPV.

Pregnancy Complications, Infectious - virology

Prospective Studies

Humans

Risk Factors

Tumor Virus Infections - diagnosis

DNA, Viral - analysis

Infectious Disease Transmission, Vertical

Papillomaviridae - isolation & purification

Papillomavirus Infections - diagnosis

Pregnancy

Pregnancy Complications, Infectious - etiology

Tumor Virus Infections - transmission

Adolescent

Adult

Female

Papillomavirus Infections - etiology

Tumor Virus Infections - etiology

Infant, Newborn

Papillomavirus Infections - transmission

Pregnancy Complications, Infectious - diagnosis

Details

Title: Subtitle: Perinatal transmission and maternal risks of human papillomavirus infection
Creators: E M Smith - Department of Preventive Medicine, University of Iowa, College of Medicine, Iowa City 52242, USA
S R Johnson
T Cripe
S Perlman
G McGuinness
D Jiang
L Cripe
L P Turek
Resource Type: Journal article
Publication Details: Cancer detection and prevention, Vol.19(2), pp.196-205
PMID: 7750107
NLM abbreviation: Cancer Detect Prev
ISSN: 0361-090X
eISSN: 1873-443X
Publisher: England
Grant note: 1 K07 CA 1181-01A1 / NCI NIH HHS
Language: English
Date published: 1995
Academic Unit: Microbiology and Immunology; Stead Family Department of Pediatrics; Epidemiology; Pathology; Iowa Neuroscience Institute; Obstetrics and Gynecology; Infectious Disease (Pediatrics)
Record Identifier: 9983777477602771

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