Journal article
Perioperative Inotrope Therapy and Atrial Fibrillation Following Coronary Artery Bypass Graft Surgery: Evidence of a Racial Disparity
Pharmacotherapy, Vol.37(3), pp.297-304
03/2017
DOI: 10.1002/phar.1894
PMCID: PMC5505772
PMID: 28052357
Abstract
Following coronary artery bypass graft (CABG) surgery, mortality rates are significantly higher among black patients who experience postoperative atrial fibrillation (POAF). Perioperative inotropic therapy (PINOT) was associated with POAF in previous reports, but the extent to which race influences this association is unknown. In the present study, the relationship between PINOT, race, and POAF was examined in patients undergoing CABG surgery.
Clinical records were examined from a prospectively maintained cohort of 11,855 patients (median age 64 yrs; 70% male; 16% black) undergoing primary isolated CABG at a large cardiovascular institute in the southeastern region of the United States. Relative risk (RR) and 95% confidence intervals (CIs) were computed using log-binomial regression.
The association between PINOT and POAF was significantly increased among black patients (adjusted RR 1.7, CI 1.4-2.0) compared with white patients (adjusted RR 1.3, CI 1.2-1.4) (p
= 0.013).
These findings suggest that PINOT may be disproportionately associated with POAF among black patients undergoing CABG surgery. Additional studies are needed to examine further the potential underlying mechanisms of this association.
Details
- Title: Subtitle
- Perioperative Inotrope Therapy and Atrial Fibrillation Following Coronary Artery Bypass Graft Surgery: Evidence of a Racial Disparity
- Creators
- Jimmy T Efird - School of Medicine and Public Health, University of Newcastle, Callaghan, New South Wales, AustraliaAndy C Kiser - Department of Cardiovascular Sciences, Brody School of Medicine, Greenville, North CarolinaPatricia B Crane - Office of the Dean, College of Nursing, East Carolina University, Greenville, North CarolinaHope Landrine - Center for Health Disparities, Brody School of Medicine, Greenville, North CarolinaLinda C Kindell - Department of Cardiovascular Sciences, Brody School of Medicine, Greenville, North CarolinaMargaret-Ann Nelson - Department of Pharmacology and Toxicology, Brody School of Medicine, Greenville, North CarolinaCharulata Jindal - School of Medicine and Public Health, University of Newcastle, Callaghan, New South Wales, AustraliaDaniel F Sarpong - Center for Minority Health and Health Disparities Research and Education, Xavier University of Louisiana, New Orleans, LouisianaWilliam F Griffin - Department of Internal Medicine, Medical University of South Carolina, Charleston, South CarolinaT Bruce Ferguson - Department of Cardiovascular Sciences, Brody School of Medicine, Greenville, North CarolinaW Randolph Chitwood - Department of Cardiovascular Sciences, Brody School of Medicine, Greenville, North CarolinaStephen W Davies - Department of General Surgery, University of Virginia School of Medicine, Charlottesville, VirginiaAlan P Kypson - Department of Cardiovascular Sciences, Brody School of Medicine, Greenville, North CarolinaPreeti Gudimella - Department of Pharmacology and Toxicology, Brody School of Medicine, Greenville, North CarolinaEthan J Anderson - Department of Pharmaceutical Sciences and Experimental Therapeutics, College of Pharmacy, Fraternal Order of Eagles Diabetes Research Center, University of Iowa, Iowa City, Iowa
- Resource Type
- Journal article
- Publication Details
- Pharmacotherapy, Vol.37(3), pp.297-304
- DOI
- 10.1002/phar.1894
- PMID
- 28052357
- PMCID
- PMC5505772
- NLM abbreviation
- Pharmacotherapy
- ISSN
- 0277-0008
- eISSN
- 1875-9114
- Publisher
- United States
- Grant note
- R01 HL122863 / NHLBI NIH HHS
- Language
- English
- Date published
- 03/2017
- Academic Unit
- Pharmaceutical Sciences and Experimental Therapeutics; Fraternal Order of Eagles Diabetes Research Center; Health, Sport, and Human Physiology
- Record Identifier
- 9984065692202771
Metrics
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