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Perioperative Management of a Patient With Giant Axonal Neuropathy
Journal article   Open access

Perioperative Management of a Patient With Giant Axonal Neuropathy

Hiromi Kako, Arlyne Thung, Allan Beebe, Jan Klamar and Joseph D. Tobias
Journal of medical cases, Vol.6(11), pp.512-516
2015
DOI: 10.14740/jmc2346w
url
https://doi.org/10.14740/jmc2346wView
Published (Version of record) Open Access

Abstract

Giant axonal neuropathy (GAN) is a rare, autosomal recessive, progressive neurodegenerative disorder affecting both the central and peripheral nervous systems. The aberrant accumulation of cytoskeletal-associated proteins causes neurodegeneration resulting in both motor and sensory dysfunction. Given the invariable and progressive involvement of the neuromuscular system, anesthetic care is frequently needed to correct the orthopedic sequelae of the disorder. We present a 12-year-old girl with GAN who required anesthetic care for posterior spinal fusion to treat scoliosis. Previous reports of anesthetic care for patients with GAN are reviewed, and the perioperative considerations of these patients are discussed.
Giant axonal neuropathy Spinal fusion Neuromuscular scoliosis Neurodegenerative disorder

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