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Perioperative care of a patient with neuronal ceroid lipofuscinoses
Journal article   Open access   Peer reviewed

Perioperative care of a patient with neuronal ceroid lipofuscinoses

Hiromi Kako, David P. Martin and Joseph D. Tobias
Saudi journal of anaesthesia, Vol.7(3), pp.336-340
07/2013
DOI: 10.4103/1658-354X.115329
PMCID: PMC3757811
PMID: 24015141
url
https://doi.org/10.4103/1658-354X.115329View
Published (Version of record) Open Access

Abstract

The neuronal ceroid lipofuscinoses (NCL) are a group of inherited, autosomal recessive, and progressive neurodegenerative diseases, which result from an enzymatic defect or the deficiency of a transmembrane protein, leading to the accumulation of lipopigments (lipofuscin) in various tissues. NCL results in the impairment of function in several end-organs including the central nervous system with loss of cognitive and motor function, myoclonus, and intractable seizures. Additional involvement includes the cardiovascular system with arrhythmias and bradycardia as well as impairment of thermoregulation leading to perioperative hypothermia. Given the complexity of the end-organ involvement and the progressive nature of the disorder, the anesthetic care of such patients can be challenging. Till date, there are a limited number of reports regarding the anesthetic management of patients with NCL. We present an 18-year-old patient with NCL who required anesthetic care during replacement of a vagal nerve stimulator. Previous reports of anesthetic care for these patients are reviewed, the end-organ involvement of NCL discussed, and options for anesthetic care presented.
Batten disease Jansky-Bielschowsky disease Neuronal ceroid lipofuscinoses

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