Journal article
Perioperative cytokine levels portend early death after pancreatectomy for ductal adenocarcinoma
Journal of surgical oncology, Vol.117(6), pp.1260-1266
05/01/2018
DOI: 10.1002/jso.24940
PMID: 29205349
Abstract
BackgroundSoluble signaling molecules may play an important role in malignant pathogenesis. We hypothesize that perioperative cytokine levels are associated with outcomes in patients with pancreatic adenocarcinoma (PDAC) undergoing surgical resection.
MethodsOne hundered and eighteen patients with benign or malignant pancreatic disease were enrolled in a prospective study through a protocol for banking biologic samples. Peripheral blood was drawn at time of operation, and a multiplex cytokine assay was performed. Statistical analysis was via (2) and Kaplan Meier methods.
ResultsOf 118 patients enrolled, 85 (72%) had a diagnosis of PDAC, and 60 (70%) ultimately underwent partial pancreatectomy. Cytokine levels were not associated with postoperative complications in this initial cohort. A plasma level of monocyte chemoattractant protein-1 (MCP-1) pg/mL 118 was associated with better overall survival (OS) (median survival 21 months vs 12.8 months, P=0.023), as was non-detectable interleukin-8 (IL-8) (19 months) versus detectable IL-8 (12.8 months, P=0.05). Patients with both MCP-1 >118pg/mL and detectable IL-8 had a median survival of 10.6 months (P=0.028).
ConclusionsMCP-1 and IL-8 cytokine levels are associated with decreased survival following pancreatectomy for PDAC, and may be useful biomarkers. Measurement of these cytokine levels at different time points in future investigations will be important to validate these findings.
Details
- Title: Subtitle
- Perioperative cytokine levels portend early death after pancreatectomy for ductal adenocarcinoma
- Creators
- Heather L. Lewis - The Ohio State UniversityJeff M. Chakedis - The Ohio State UniversityErin Talbert - The Ohio State UniversityEricka Haverick - The Ohio State UniversityPriyani Rajasekera - The Ohio State UniversityPhilip Hart - The Ohio State UniversityMark Bloomston - 21st Century OncologyMary Dillhoff - The Ohio State UniversityTimothy M. Pawlik - The Ohio State UniversityDenis Guttridge - The Ohio State UniversityCarl R. Schmidt - The Ohio State University
- Resource Type
- Journal article
- Publication Details
- Journal of surgical oncology, Vol.117(6), pp.1260-1266
- Publisher
- Wiley
- DOI
- 10.1002/jso.24940
- PMID
- 29205349
- ISSN
- 0022-4790
- eISSN
- 1096-9098
- Number of pages
- 7
- Language
- English
- Date published
- 05/01/2018
- Academic Unit
- Fraternal Order of Eagles Diabetes Research Center; Health and Human Physiology; Internal Medicine
- Record Identifier
- 9984259648502771
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