Journal article
Peripartum cardiomyopathy with a history of doxorubicin therapy: case report & review of literature
Proceedings in obstetrics and gynecology, Vol.8(1), 5
11/09/2017
DOI: 10.17077/2154-4751.1377
Abstract
Background: Peripartum cardiomyopathy and doxorubicin-induced cardiomyopathy are well described conditions but there is little description in the literature of both occurring together.
Case: A 29 year old G1P0 with a remote history of childhood chondroblastic osteosarcoma treated with high-dose doxorubicin therapy who developed minimally symptomatic cardiomyopathy during her pregnancy with ejection fraction reaching as low as 20-30%. She delivered via primary low-transverse cesarean section at 37 weeks complicated by uterine atony with an unremarkable recovery. Cardiomyopathy was treated with metoprolol and enalapril and she achieved ejection fraction of 44% at one year follow-up with complete return to baseline activity.
Discussion: We present a woman with a history of doxorubicin therapy who developed peripartum cardiomyopathy and recovered symptomatically after one year. Although treatment of peripartum cardiomyopathy regardless of etiology is well-defined, there are few reports and no standard guidelines for special considerations in pregnant women with a history of doxorubicin therapy, a topic that may warrant further investigation.
Details
- Title: Subtitle
- Peripartum cardiomyopathy with a history of doxorubicin therapy: case report & review of literature
- Creators
- Sraavya S Akella - University of Iowa Carver College of Medicine, Iowa City, IowaSarah A Shaffer - University of Iowa Hospitals and Clinics, Department of Obstetrics and Gynecology, Iowa City, Iowa
- Resource Type
- Journal article
- Publication Details
- Proceedings in obstetrics and gynecology, Vol.8(1), 5
- DOI
- 10.17077/2154-4751.1377
- ISSN
- 2154-4751
- eISSN
- 2154-4751
- Copyright
- Copyright © 2018 Sraavya S. Akella and Sarah A. Shaffer
- Language
- English
- Date published
- 11/09/2017
- Academic Unit
- Obstetrics and Gynecology
- Record Identifier
- 9983931232902771
Metrics
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