Peripheral combined hamartoma of the retina and retinal pigment epithelium with remote peripapillary choroidal neovascular membrane

Thomas A Lazzarini; Hasenin Al-khersan; Nimesh A Patel; Jonathan F Russell; Kenneth C Fan; Giselle De Oliveira; Catherin I Negron; Elias Mavrofrides; Audina M Berrocal

doi:10.1016/j.ajoc.2020.100954

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Peripheral combined hamartoma of the retina and retinal pigment epithelium with remote peripapillary choroidal neovascular membrane

Journal article

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Peripheral combined hamartoma of the retina and retinal pigment epithelium with remote peripapillary choroidal neovascular membrane

Thomas A Lazzarini, Hasenin Al-khersan, Nimesh A Patel, Jonathan F Russell, Kenneth C Fan, Giselle De Oliveira, Catherin I Negron, Elias Mavrofrides and Audina M Berrocal

American journal of ophthalmology case reports, Vol.20, p.100954

12/2020

DOI: 10.1016/j.ajoc.2020.100954

PMCID: PMC7551977

PMID: 33083636

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Abstract

To describe the first reported case of combined hamartoma of the retina and retinal pigment epithelium (CHRRPE) associated with a remote choroidal neovascular membrane (CNVM). A 19-month-old girl with a normal prenatal and infantile history presented with esotropia of the left eye. Fundus examination demonstrated a large, elevated, charcoal-colored lesion in the nasal equatorial retina. There was dragging of the nasal retinal vessels and a retinal fold, presumed to have resulted from nasal traction from the lesion. There was also subretinal hemorrhage in the peripapillary macula. Multimodal imaging demonstrated a peripapillary choroidal neovascular membrane (CNVM) underlying the retinal fold. There was no leakage within the tumor or secondary retinal neovascularization. Examination of the fellow eye was unremarkable. The patient was diagnosed with peripheral CHRRPE with associated peripapillary CNVM. She was treated with serial intravitreal bevacizumab to the affected eye which resulted in a reduction in leakage from the CNVM and resolution of the subretinal hemorrhage. The CHRRPE remained stable on follow-up. Peripheral CHRRPE can rarely be associated with a remote CNVM.

Bevacizumab

Choroidal neovascular membrane

Combined hamartoma of retina and retinal pigment epithelium

Pediatric retina

Retina

Secondary choroidal neovascularization

Details

Title: Subtitle: Peripheral combined hamartoma of the retina and retinal pigment epithelium with remote peripapillary choroidal neovascular membrane
Creators: Thomas A Lazzarini - Bascom Palmer Eye Institute
Hasenin Al-khersan - Bascom Palmer Eye Institute, Miami, FL, USA
Nimesh A Patel - Bascom Palmer Eye Institute
Jonathan F Russell - Bascom Palmer Eye Institute
Kenneth C Fan - Bascom Palmer Eye Institute
Giselle De Oliveira - Bascom Palmer Eye Institute
Catherin I Negron - Bascom Palmer Eye Institute
Elias Mavrofrides - Retina Institute
Audina M Berrocal - Bascom Palmer Eye Institute
Resource Type: Journal article
Publication Details: American journal of ophthalmology case reports, Vol.20, p.100954
DOI: 10.1016/j.ajoc.2020.100954
PMID: 33083636
PMCID: PMC7551977
NLM abbreviation: Am J Ophthalmol Case Rep
ISSN: 2451-9936
eISSN: 2451-9936
Publisher: Elsevier Inc
Grant note: DOI: 10.13039/100000002, name: NIH, award: EY14801-16; DOI: 10.13039/100001818, name: Research to Prevent Blindness Unrestricted, award: GR004596
Language: English
Date published: 12/2020
Academic Unit: Ophthalmology and Visual Sciences
Record Identifier: 9984187263902771

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