Peripheral inflammation during abnormal mood states in bipolar I disorder

Jess G Fiedorowicz; Alan R Prossin; Casey P Johnson; Gary E Christensen; Vincent A Magnotta; John A Wemmie

doi:10.1016/j.jad.2015.08.036

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Peripheral inflammation during abnormal mood states in bipolar I disorder

Journal article

Open access

Peer reviewed

Peripheral inflammation during abnormal mood states in bipolar I disorder

Jess G Fiedorowicz, Alan R Prossin, Casey P Johnson, Gary E Christensen, Vincent A Magnotta and John A Wemmie

Journal of affective disorders, Vol.187, pp.172-178

11/15/2015

DOI: 10.1016/j.jad.2015.08.036

PMCID: PMC4587340

PMID: 26339927

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Abstract

Bipolar disorder carries a substantive morbidity and mortality burden, particularly related to cardiovascular disease. Abnormalities in peripheral inflammatory markers, which have been commonly reported in case-control studies, potentially link these co-morbidities. However, it is not clear whether inflammatory markers change episodically in response to mood states or are indicative of chronic pro-inflammatory activity, regardless of mood, in bipolar disorder. Investigations focused on comparing concentrations of specific inflammatory cytokines associated with immune activation status (primary outcome=tumor necrosis factor alpha (TNF-α)) in 37 participants with bipolar disorder across 3 mood states (mania N=15, depression N=9, normal mood N=13) and 29 controls without a psychiatric disorder (total N=66). Cytokine levels were also compared to T1ρ, a potential neuroimaging marker for inflammation, in select brain regions in a subsample (N=39). Participants with bipolar disorder and healthy controls did not differ significantly in inflammatory cytokine concentrations. However, compared to cases with normal mood, cases with abnormal mood states (mania and depression) had significantly elevated levels of TNF-α, its soluble receptors (sTNFR1/sTNFR2), other macrophage-derived cytokines (interleukin 1β (IL-1β), IL-6, IL-10, and IL-18) in addition to IL-4, interferon-γ, monocyte chemotactic protein-1, fibroblast growth factor β, and vascular endothelial growth factor. Cytokine levels were not correlated with signals from T1ρ imaging in selected structures (amygdalae, hippocampi, hypothalamus, anterior cingulate gyrus, and middle frontal gyrus). Participants were not followed prospectively across mood states. Activation of inflammatory markers was found in abnormal mood states of bipolar disorder. Longitudinal study of individuals with mood disorders is needed to confirm these findings and to elucidate the time course of any such changes. •Elevations in TNF-α, its soluble and other macrophage-derived cytokines appear most prominent in abnormal mood states of bipolar disorder.•Magnetic resonance imaging, using T1ρ, does not identify changes in the brain associated with these cytokines.•Longitudinal study is needed to better understand the relationship between cytokines and mood states in bipolar disorder.

Neuroimaging

Bipolar disorder

Inflammation

Affect

Details

Title: Subtitle: Peripheral inflammation during abnormal mood states in bipolar I disorder
Creators: Jess G Fiedorowicz - Department of Psychiatry, Roy J. and Lucille A. Carver College of Medicine, The University of Iowa, 200 Hawkins Drive W278GH, Iowa City, IA 52242-1057, USA
Alan R Prossin - Department of Psychiatry, University of Texas Health Science Center at Houston, Houston, TX, USA
Casey P Johnson - Department of Radiology, Roy J. and Lucille A. Carver College of Medicine, The University of Iowa, 200 Hawkins Drive W278GH, Iowa City, IA 52242-1057, USA
Gary E Christensen - Department of Radiation Oncology, Roy J. and Lucille A. Carver College of Medicine, The University of Iowa, 200 Hawkins Drive W278GH, Iowa City, IA 52242-1057, USA
Vincent A Magnotta - Department of Psychiatry, Roy J. and Lucille A. Carver College of Medicine, The University of Iowa, 200 Hawkins Drive W278GH, Iowa City, IA 52242-1057, USA
John A Wemmie - Department of Psychiatry, Roy J. and Lucille A. Carver College of Medicine, The University of Iowa, 200 Hawkins Drive W278GH, Iowa City, IA 52242-1057, USA
Resource Type: Journal article
Publication Details: Journal of affective disorders, Vol.187, pp.172-178
DOI: 10.1016/j.jad.2015.08.036
PMID: 26339927
PMCID: PMC4587340
NLM abbreviation: J Affect Disord
ISSN: 0165-0327
eISSN: 1573-2517
Publisher: Elsevier B.V
Language: English
Date published: 11/15/2015
Academic Unit: Roy J. Carver Department of Biomedical Engineering; Radiology; Electrical and Computer Engineering; Molecular Physiology and Biophysics; Psychiatry; Epidemiology; Iowa Neuroscience Institute; Radiation Oncology; Radiation Research Laboratory; Neurosurgery; Internal Medicine
Record Identifier: 9984003957402771

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