Journal article
Peripheral neuropathies caused by mutations in the myelin protein zero
Journal of the neurological sciences, Vol.242(1), pp.55-66
2006
DOI: 10.1016/j.jns.2005.11.015
PMID: 16414078
Abstract
Charcot-Marie-Tooth disease type 1B (CMT1B) is caused by mutations in the major PNS myelin protein myelin protein zero (MPZ). MPZ is a member of the immunoglobulin supergene family and functions as an adhesion molecule helping to mediate compaction of PNS myelin. Mutations in MPZ appear to either disrupt myelination during development, leading to severe early onset neuropathies, or to disrupt axo–glial interactions leading to late onset neuropathies in adulthood. Identifying molecular pathways involved in early and late onset CMT1B will be crucial to understand how MPZ mutations cause CMT1B so that rational therapies for both early and late onset neuropathies can be developed.
Details
- Title: Subtitle
- Peripheral neuropathies caused by mutations in the myelin protein zero
- Creators
- Michael E Shy - Wayne State University, Department of Neurology, 421 Ea Canfield, Elliman Bldg 3206, Detroit, MI 48201, United States
- Resource Type
- Journal article
- Publication Details
- Journal of the neurological sciences, Vol.242(1), pp.55-66
- Publisher
- Elsevier B.V
- DOI
- 10.1016/j.jns.2005.11.015
- PMID
- 16414078
- ISSN
- 0022-510X
- eISSN
- 1878-5883
- Language
- English
- Date published
- 2006
- Academic Unit
- Neurology; Molecular Physiology and Biophysics; Stead Family Department of Pediatrics; Iowa Neuroscience Institute
- Record Identifier
- 9984020765402771
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