Journal article
Peripheral regulation of T cells by dendritic cells during infection
Immunologic research, Vol.59(1-3), pp.66-72
08/2014
DOI: 10.1007/s12026-014-8530-3
PMID: 24838143
Abstract
It is well accepted that T cell responses are integral in providing protection during pathogenic infections. In numerous tissues, T cell responses are generated to combat infection. Typically, these T cell responses are primed in draining lymph nodes (LN) by dendritic cells (DC) that have migrated from the infected tissue. Previously, it was thought that after the initial encounter between DC and T cells in the LN, the T cells underwent a programmed response. However, it has become increasingly clear that direct interactions between DCs and T cells in infected, peripheral tissues can modulate the activation, effector function, tissue residence, and memory responses of these T cells. This review will highlight the contribution of local, direct DC: T cell interactions to the regulation of T cell responses in various tissues during inflammation and infection .
Details
- Title: Subtitle
- Peripheral regulation of T cells by dendritic cells during infection
- Creators
- Emily A Hemann - Department of Pathology and Interdisciplinary Graduate Program in Immunology, University of Iowa, Iowa City, IA, 52242, USAKevin L Legge
- Resource Type
- Journal article
- Publication Details
- Immunologic research, Vol.59(1-3), pp.66-72
- Publisher
- United States
- DOI
- 10.1007/s12026-014-8530-3
- PMID
- 24838143
- ISSN
- 0257-277X
- eISSN
- 1559-0755
- Grant note
- AI071085 / NIAID NIH HHS R56 AI071085 / NIAID NIH HHS T32 AI007485 / NIAID NIH HHS T32 AI007533 / NIAID NIH HHS
- Language
- English
- Date published
- 08/2014
- Academic Unit
- Microbiology and Immunology; Pathology
- Record Identifier
- 9984047626802771
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