Peripherally induced brain tissue-resident memory CD8 + T cells mediate protection against CNS infection

Stina L Urban; Isaac J Jensen; Qiang Shan; Lecia L Pewe; Hai-Hui Xue; Vladimir P Badovinac; John T Harty

doi:10.1038/s41590-020-0711-8

Back

Peripherally induced brain tissue-resident memory CD8 + T cells mediate protection against CNS infection

Journal article

Peer reviewed

Peripherally induced brain tissue-resident memory CD8 + T cells mediate protection against CNS infection

Stina L Urban, Isaac J Jensen, Qiang Shan, Lecia L Pewe, Hai-Hui Xue, Vladimir P Badovinac and John T Harty

Nature immunology, Vol.21(8), pp.938-949

08/2020

DOI: 10.1038/s41590-020-0711-8

PMCID: PMC7381383

PMID: 32572242

Files and links (1)

url

https://www.ncbi.nlm.nih.gov/pmc/articles/7381383View

Open Access

Abstract

The central nervous system (CNS) is classically viewed as immune-privileged; however, recent advances highlight interactions between the peripheral immune system and CNS in controlling infections and tissue homeostasis. Tissue-resident memory (T ) CD8 T cells in the CNS are generated after brain infections, but it is unknown whether CNS infection is required to generate brain T cells. We show that peripheral infections generate antigen-specific CD8 memory T cells in the brain that adopt a unique T signature. Upon depletion of circulating and perivascular memory T cells, this brain signature was enriched and the surveilling properties of brain T cells was revealed by intravital imaging. Notably, peripherally induced brain T cells showed evidence of rapid activation and enhanced cytokine production and mediated protection after brain infections. These data reveal that peripheral immunizations can generate brain T cells and will guide potential use of T cells as therapeutic strategies against CNS infections and neurological diseases.

Animals

Bacterial Infections - immunology

Brain - cytology

Brain - immunology

CD8-Positive T-Lymphocytes - immunology

Central Nervous System Infections - immunology

Immunologic Memory - immunology

Lymphocyte Activation - immunology

Mice

Virus Diseases - immunology

Details

Title: Subtitle: Peripherally induced brain tissue-resident memory CD8 + T cells mediate protection against CNS infection
Creators: Stina L Urban - University of Iowa
Isaac J Jensen - University of Iowa
Qiang Shan - Hackensack University Medical Center
Lecia L Pewe - University of Iowa
Hai-Hui Xue - VA New Jersey Health Care System
Vladimir P Badovinac - University of Iowa
John T Harty - University of Iowa
Resource Type: Journal article
Publication Details: Nature immunology, Vol.21(8), pp.938-949
DOI: 10.1038/s41590-020-0711-8
PMID: 32572242
PMCID: PMC7381383
NLM abbreviation: Nat Immunol
ISSN: 1529-2908
eISSN: 1529-2916
Grant note: R01 AI114543 / NIAID NIH HHS T32 AI007343 / NIAID NIH HHS R01 AI121080 / NIAID NIH HHS R01 AI042767 / NIAID NIH HHS I01 BX002903 / BLRD VA R01 AI139874 / NIAID NIH HHS
Language: English
Date published: 08/2020
Academic Unit: Microbiology and Immunology; Pathology
Record Identifier: 9984180925802771

Metrics

39 Record Views

94 Times Cited - Web of Science