Peritraumatic Plasma Omega-3 Fatty Acid Concentration Predicts Chronic Pain Severity Following Thermal Burn Injury

Matthew C Mauck; Chloe E Barton; Andrew S Tungate; Jeffrey W Shupp; Rachel Karlnoski; David J Smith; Felicia N Williams; Samuel W Jones; Christopher Sefton; Kyle McGrath; Bruce A Cairns; Samuel A McLean

doi:10.1093/jbcr/irab071

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Peritraumatic Plasma Omega-3 Fatty Acid Concentration Predicts Chronic Pain Severity Following Thermal Burn Injury

Journal article

Peer reviewed

Peritraumatic Plasma Omega-3 Fatty Acid Concentration Predicts Chronic Pain Severity Following Thermal Burn Injury

Matthew C Mauck, Chloe E Barton, Andrew S Tungate, Jeffrey W Shupp, Rachel Karlnoski, David J Smith, Felicia N Williams, Samuel W Jones, Christopher Sefton, Kyle McGrath, …

Journal of burn care & research, Vol.43(1), pp.109-114

01/05/2022

DOI: 10.1093/jbcr/irab071

PMCID: PMC8737082

PMID: 33895836

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https://www.ncbi.nlm.nih.gov/pmc/articles/8737082View

Open Access

Abstract

Chronic pain is a significant comorbidity of burn injury affecting up to 60% of survivors. Currently, no treatments are available to prevent chronic pain after burn injury. Accumulating evidence suggests that omega-3 fatty acids (O3FAs) improve symptoms across a range of painful conditions. In this study, we evaluated whether low peritraumatic levels of O3FA predict greater pain severity during the year after burn injury. Burn survivors undergoing skin autograft were recruited from three participating burn centers. Plasma O3FA (n = 77) levels were assessed in the early aftermath of burn injury using liquid chromatography/mass spectrometry, and pain severity was assessed via the 0 to 10 numeric rating scale for 1 year following burn injury. Repeated-measures linear regression analyses were used to evaluate the association between peritraumatic O3FA concentrations and pain severity during the year following burn injury. Peritraumatic O3FA concentration and chronic pain severity were inversely related; lower levels of peritraumatic O3FAs predicted worse pain outcomes (β = -0.002, P = .020). Future studies are needed to evaluate biological mechanisms mediating this association and to assess the ability of O3FAs to prevent chronic pain following burn injury.

Adolescent

Adult

Aged

Biomarkers - blood

Burns - complications

Chronic Pain - etiology

Fatty Acids, Omega-3 - blood

Female

Humans

Male

Middle Aged

Pain Measurement

Predictive Value of Tests

Details

Title: Subtitle: Peritraumatic Plasma Omega-3 Fatty Acid Concentration Predicts Chronic Pain Severity Following Thermal Burn Injury
Creators: Matthew C Mauck - University of North Carolina at Chapel Hill
Chloe E Barton - University of North Carolina at Chapel Hill
Andrew S Tungate - University of North Carolina at Chapel Hill
Jeffrey W Shupp - MedStar Washington Hospital Center
Rachel Karlnoski - University of South Florida
David J Smith - University of South Florida
Felicia N Williams - University of North Carolina at Chapel Hill
Samuel W Jones - University of North Carolina at Chapel Hill
Christopher Sefton - University of North Carolina at Chapel Hill
Kyle McGrath - University of North Carolina at Chapel Hill
Bruce A Cairns - University of North Carolina at Chapel Hill
Samuel A McLean - University of North Carolina at Chapel Hill
Resource Type: Journal article
Publication Details: Journal of burn care & research, Vol.43(1), pp.109-114
DOI: 10.1093/jbcr/irab071
PMID: 33895836
PMCID: PMC8737082
NLM abbreviation: J Burn Care Res
ISSN: 1559-047X
eISSN: 1559-0488
Grant note: NICHD NIH HHS K12 HD001441 / NICHD NIH HHS K12HD001441 / NIH HHS
Language: English
Date published: 01/05/2022
Academic Unit: Surgery
Record Identifier: 9984756257502771

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3 Times Cited - Web of Science