Peritraumatic Vitamin D Levels Predict Chronic Pain Severity and Contribute to Racial Differences in Pain Outcomes Following Major Thermal Burn Injury

Matthew C Mauck; Chloe E Barton; Andrew Tungate; Jeffrey W Shupp; Rachel Karlnoski; David J Smith; Felicia N Williams; Samuel W Jones; Kyle V McGrath; Bruce A Cairns; Samuel A McLean

doi:10.1093/jbcr/irab031

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Peritraumatic Vitamin D Levels Predict Chronic Pain Severity and Contribute to Racial Differences in Pain Outcomes Following Major Thermal Burn Injury

Journal article

Peer reviewed

Peritraumatic Vitamin D Levels Predict Chronic Pain Severity and Contribute to Racial Differences in Pain Outcomes Following Major Thermal Burn Injury

Matthew C Mauck, Chloe E Barton, Andrew Tungate, Jeffrey W Shupp, Rachel Karlnoski, David J Smith, Felicia N Williams, Samuel W Jones, Kyle V McGrath, Bruce A Cairns, …

Journal of burn care & research, Vol.42(6), pp.1186-1191

11/24/2021

DOI: 10.1093/jbcr/irab031

PMCID: PMC8921735

PMID: 33564878

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https://www.ncbi.nlm.nih.gov/pmc/articles/8921735View

Open Access

Abstract

Major thermal burn injuries result in approximately 40,000 hospitalizations in the United States each year. Chronic pain affects up to 60% of burn survivors, and Black Americans have worse chronic pain outcomes than White Americans. Mechanisms of chronic pain pathogenesis after burn injury, and accounting for these racial differences, remain poorly understood. Due to socioeconomic disadvantage and differences in skin absorption, Black Americans have an increased prevalence of Vitamin D deficiency. We hypothesized that peritraumatic Vitamin D levels predict chronic pain outcomes after burn injury and contribute to racial differences in pain outcomes. Among burn survivors (n = 77, 52% White, 48% Black, 77% male), peritraumatic Vitamin D levels were more likely to be deficient in Blacks vs Whites (27/37 [73%] vs 14/40 [35%], P < .001). Peritraumatic Vitamin D levels were inversely associated with chronic post-burn pain outcomes across all burn injury survivors, including those who were and were not Vitamin D deficient, and accounted for approximately one-third of racial differences in post-burn pain outcome. Future studies are needed to evaluate potential mechanisms mediating the effect of Vitamin D on post-burn pain outcomes and the potential efficacy of Vitamin D in improving pain outcomes and reducing racial differences.

Burns - blood

Burns - ethnology

Cross-Sectional Studies

Female

Humans

Male

Pain Measurement - statistics & numerical data

Prevalence

Race Factors - statistics & numerical data

Risk Assessment

Risk Factors

United States

Vitamin D Deficiency - blood

Vitamin D Deficiency - ethnology

Wound Infection - etiology

Details

Title: Subtitle: Peritraumatic Vitamin D Levels Predict Chronic Pain Severity and Contribute to Racial Differences in Pain Outcomes Following Major Thermal Burn Injury
Creators: Matthew C Mauck - University of North Carolina at Chapel Hill
Chloe E Barton - University of North Carolina at Chapel Hill
Andrew Tungate - University of North Carolina at Chapel Hill
Jeffrey W Shupp - MedStar Washington Hospital Center
Rachel Karlnoski - University of South Florida
David J Smith - University of South Florida
Felicia N Williams - Jaycee Burn Center
Samuel W Jones - Jaycee Burn Center
Kyle V McGrath - University of North Carolina at Chapel Hill
Bruce A Cairns - Jaycee Burn Center
Samuel A McLean - University of North Carolina at Chapel Hill
Resource Type: Journal article
Publication Details: Journal of burn care & research, Vol.42(6), pp.1186-1191
DOI: 10.1093/jbcr/irab031
PMID: 33564878
PMCID: PMC8921735
NLM abbreviation: J Burn Care Res
ISSN: 1559-047X
eISSN: 1559-0488
Grant note: UNC BIRCWH 3K12HD001441-18S1 / NIH HHS K12 HD001441 / NICHD NIH HHS
Language: English
Date published: 11/24/2021
Academic Unit: Surgery
Record Identifier: 9984755386702771

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