Periventricular anteroventral third ventricle lesions diminish the pressor response produced by systemic injection of the N-methyl- d-aspartate receptor antagonist MK-801

Erin J Whalen; Terry G Beltz; Stephen J Lewis; Alan Kim Johnson

doi:10.1016/S0006-8993(99)01595-4

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Periventricular anteroventral third ventricle lesions diminish the pressor response produced by systemic injection of the N-methyl- d-aspartate receptor antagonist MK-801

Journal article

Peer reviewed

Periventricular anteroventral third ventricle lesions diminish the pressor response produced by systemic injection of the N-methyl- d-aspartate receptor antagonist MK-801

Erin J Whalen, Terry G Beltz, Stephen J Lewis and Alan Kim Johnson

Brain research, Vol.836(1), pp.210-212

1999

DOI: 10.1016/S0006-8993(99)01595-4

PMID: 10415421

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Abstract

This study examined whether electrolytic ablation of the periventricular anteroventral third ventricle (AV3V) would affect the increases in mean arterial blood pressure (MAP) and heart rate (HR) in conscious rats produced by systemic injection of the centrally acting N-methyl- d-aspartate (NMDA) receptor ion-channel blocker, (+)-5-methyl-10,11-dihydro-5H-dibenzo[a,d]cyclohepten-5,10-imine (MK-801; 250 μg/kg, i.v.). MK-801 produced a smaller increase in MAP in rats with AV3V lesions than in sham-lesion rats (+36±2% vs. +52±5%, respectively, P<0.05). In contrast, MK-801 produced similar increases in HR in the AV3V- and sham-lesion rats (+28±3% vs. +22±4%, respectively, P>0.05). These findings demonstrate that the MK-801-induced pressor response is dependent upon the integrity of the AV3V region, whereas the MK-801-induced tachycardia is not.

Blood pressure

Heart rate

N-methyl- d-aspartate receptor

Periventricular anteroventral third ventricle

Details

Title: Subtitle: Periventricular anteroventral third ventricle lesions diminish the pressor response produced by systemic injection of the N-methyl- d-aspartate receptor antagonist MK-801
Creators: Erin J Whalen - Department of Pharmacology, University of Iowa, Iowa City, IA 52242-1109, USA
Terry G Beltz - Department of Psychology, University of Iowa, 11 Seashore Hall E., Iowa City, IA 52242-1407, USA
Stephen J Lewis - Department of Pharmacology, University of Iowa, Iowa City, IA 52242-1109, USA
Alan Kim Johnson - Department of Pharmacology, University of Iowa, Iowa City, IA 52242-1109, USA
Resource Type: Journal article
Publication Details: Brain research, Vol.836(1), pp.210-212
Publisher: Elsevier B.V
DOI: 10.1016/S0006-8993(99)01595-4
PMID: 10415421
ISSN: 0006-8993
eISSN: 1872-6240
Language: English
Date published: 1999
Academic Unit: Psychological and Brain Sciences; Neuroscience and Pharmacology; Health and Human Physiology
Record Identifier: 9984213412102771

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