Journal article
Permeability of the middle ear to staphylococcal pyrogenic exotoxin in otitis media
International journal of pediatric otorhinolaryngology, Vol.1(4), pp.301-308
1980
DOI: 10.1016/0165-5876(80)90004-X
PMID: 7451031
Abstract
Middle ear permeability after instillation of staphylococcal pyrogenic exotoxin was studied in each of 12 cats, 6 of them with otitis media induced by obstructing their eustachian tubes. This is the first report that there is passage of toxin to the perilymph, cerebrospinal fluid and blood not only in diseased ears, but also in normal controls, 25 min and 12 h after exposure of the middle ear cavity and round window membrane to toxin. The data suggest a pathophysiological explanation for the association of otitis media and sensorineural hearing loss and/or endolymphatic hydrops; potentially both entities can be caused by exotoxins. It also documents the extraordinary capabilities of movement of staphylococcal exotoxin.
Details
- Title: Subtitle
- Permeability of the middle ear to staphylococcal pyrogenic exotoxin in otitis media
- Creators
- Marcos V GoycooleaMichael M PaparellaBurt GoldbergPatrick M SchlievertAnna-Mary Carpenter
- Resource Type
- Journal article
- Publication Details
- International journal of pediatric otorhinolaryngology, Vol.1(4), pp.301-308
- Publisher
- Elsevier Ireland Ltd
- DOI
- 10.1016/0165-5876(80)90004-X
- PMID
- 7451031
- ISSN
- 0165-5876
- eISSN
- 1872-8464
- Language
- English
- Date published
- 1980
- Academic Unit
- Microbiology and Immunology; Internal Medicine
- Record Identifier
- 9984002392902771
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