Journal article
Peroxiredoxin 1 protein interacts with influenza virus ribonucleoproteins and is required for efficient virus replication
Vaccine, Vol.36(30), pp.4540-4547
07/16/2018
DOI: 10.1016/j.vaccine.2018.05.125
PMID: 29921490
Abstract
Cellular proteins that support influenza virus infection represent potential therapeutic targets. Cytoplasmic egress intermediates of influenza A/WSN/33 were isolated and shown to be associated with the cellular enzymes peroxiredoxins-1 (Prdx-1) during glycerol gradient fractionation. Prdx-1 also co-localizes with influenza NP at the cell periphery late in infection. Knock-down or knockout of Prdx-1 expression inhibit influenza A replication. Inhibition of replication is not correlated with defects in initiation of infection or mRNA expression, but is correlated with inhibition of accumulation of viral proteins and vRNAs.
Details
- Title: Subtitle
- Peroxiredoxin 1 protein interacts with influenza virus ribonucleoproteins and is required for efficient virus replication
- Creators
- Xiaoxia Dai - School of Public Health, Xi’an Jiaotong University Health Science Center, Xi’an, PR ChinaNa Li - School of Public Health, Xi’an Jiaotong University Health Science Center, Xi’an, PR ChinaRichard J Roller - Department of Microbiology, University of Iowa, Iowa City, IA 52242, United States
- Resource Type
- Journal article
- Publication Details
- Vaccine, Vol.36(30), pp.4540-4547
- DOI
- 10.1016/j.vaccine.2018.05.125
- PMID
- 29921490
- NLM abbreviation
- Vaccine
- ISSN
- 0264-410X
- eISSN
- 1873-2518
- Publisher
- Elsevier Ltd
- Grant note
- DOI: 10.13039/100008893, name: University of Iowa
- Language
- English
- Date published
- 07/16/2018
- Academic Unit
- Microbiology and Immunology
- Record Identifier
- 9984002399702771
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