Journal article
Peroxisome Proliferator-Activated Receptor Gamma and Regulations by the Ubiquitin-Proteasome Systemin Pancreatic Cancer
PPAR research, Vol.2012, 367450
01/01/2012
DOI: 10.1155/2012/367450
PMCID: PMC3459232
PMID: 23049538
Abstract
Pancreatic cancer is one of the most lethal forms of human cancer. Although progress in oncology has improved outcomes in many forms of cancer, little progress has been made in pancreatic carcinoma and the prognosis of this malignancy remains grim. Several molecular abnormalities often present in pancreatic cancer have been defined and include mutations in K-ras, p53, p16, and DPC4 genes. Nuclear receptor Peroxisome Proliferator-Activated Receptor gamma (PPAR gamma) has a role in many carcinomas and has been found to be overexpressed in pancreatic cancer. It plays generally a tumor suppressor role antagonizing proteins promoting carcinogenesis such as NF-kappa B and TGF beta. Regulation of pathways involved in pancreatic carcinogenesis is effectuated by the Ubiquitin Proteasome System (UPS). This paper will examine PPAR gamma in pancreatic cancer, the regulation of this nuclear receptor by the UPS, and their relationship to other pathways important in pancreatic carcinogenesis.
Details
- Title: Subtitle
- Peroxisome Proliferator-Activated Receptor Gamma and Regulations by the Ubiquitin-Proteasome Systemin Pancreatic Cancer
- Creators
- Athina Stravodimou - Charmo UniversityGianluigi Mazzoccoli - IRCCS Sci Inst, Dept Med Sci, Div Internal Med, San Giovanni Rotondo, ItalyIoannis A. Voutsadakis - Charmo University
- Resource Type
- Journal article
- Publication Details
- PPAR research, Vol.2012, 367450
- DOI
- 10.1155/2012/367450
- PMID
- 23049538
- PMCID
- PMC3459232
- NLM abbreviation
- PPAR Res
- ISSN
- 1687-4757
- eISSN
- 1687-4765
- Publisher
- Hindawi Publishing Group
- Number of pages
- 13
- Language
- English
- Date published
- 01/01/2012
- Academic Unit
- Internal Medicine
- Record Identifier
- 9984806611302771
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